Investigating how lactate affects immune function in sepsis
Novel Role of Lactate in Sepsis Impaired Immune Function
This study is looking at how high levels of lactate in the body might affect the immune system of people who survive sepsis, with the goal of finding ways to help them stay healthier and reduce the risk of future infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Tennessee State University NIH-funded |
| Lab location | 1 site (Johnson City, United States) |
| Project ID | NIH-11000337 on NIH RePORTER |
What this research studies
This research explores the role of lactate in sepsis, a severe condition that disrupts the body's immune response. It aims to understand how elevated lactate levels may contribute to long-term immune dysfunction in sepsis survivors, potentially leading to higher mortality rates from infections. The study involves analyzing cellular responses, particularly focusing on macrophages, which are crucial for immune defense. By examining how lactate influences these immune cells, the research seeks to uncover new insights into improving outcomes for sepsis patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced sepsis and are at risk for long-term immune dysfunction.
Not a fit: Patients who have not experienced sepsis or those with other unrelated immune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance immune function in sepsis survivors, potentially reducing mortality from subsequent infections.
How similar studies have performed: Other research has indicated that targeting metabolic pathways, like lactate metabolism, can improve immune responses, suggesting potential success for this approach.
Where this research is happening
Johnson City, United States
- East Tennessee State University — Johnson City, United States (Active)
Researchers
- Principal investigator: Li, Chuanfu — East Tennessee State University
- Study coordinator: Li, Chuanfu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.