Sponsor or institution
Clinical trials and research at Dana-Farber Cancer Inst
As of November 12, 2026, Find a Trial lists 650 NIH-funded research projects at this institution, with $412.1 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 650NIH research projects
NIH-funded research (newest 40 of 650)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Helping young people with cancer understand their genetic risks
This study is creating a special program to help teenagers and young adults with hereditary cancer risks learn about their health and make smart choices, while also supporting their families along the way.
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Core administrative hub for a multifaceted cancer center program
A large, international cancer research program at Dana-Farber aims to advance a curative strategy for multiple myeloma by coordinating translational research, clinical trials, and data analysis.
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Automated, interactive lab tool to define radiation targets in cancer care
Aims to make it easier and safer to outline the area to treat in radiation therapy for cancers by using smart software and a patient-friendly interface.
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Cancer Atlas Network data hub to share big cancer data
A national project helps researchers store, harmonize, and share large cancer data collections so doctors and scientists can learn from many patients.
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Bridge-building cancer research partnership for education, outreach, and science
A joint effort between UMass Boston and Harvard Cancer Consortium to accelerate cancer research and education by connecting lower-resourced institutions with a leading cancer center.
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NexTGen: Next-Generation T cell therapy for childhood cancers
A charity-friendly overview: researchers at Dana-Farber are developing advanced engineered T-cell therapies to treat pediatric solid cancers like brain tumors and sarcomas.
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Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
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Genetic and Genomic Factors Driving Prostate Cancer in American Men
This grant looks at how inherited genes and tumor DNA affect the risk and behavior of prostate cancer in American men, with a focus on diverse populations.
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Genetic and Genomic Factors in Prostate Cancer for American Men
This project studies how inherited genes and tumor genetics influence how often prostate cancer occurs and how it behaves in American men.
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Genetic and Genomic Factors in Prostate Cancer among African American Men
A study to understand how inherited genes and tumor genetics influence the risk and behavior of prostate cancer in men, especially those of African descent.
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Genetic and Genomic Factors Shaping Prostate Cancer in American Men
This grant looks at how inherited genes and tumor DNA influence the risk and behavior of prostate cancer in American men, with a focus on diversity and ancestry.
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Genetic and Genomic Factors in Prostate Cancer among American Men
This grant studies how inherited genes and tumor genetics influence how often prostate cancer occurs and how it behaves in American men.
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Genetic and Genomic Factors in Prostate Cancer for African American Men
This grant aims to understand how inherited genes and tumor genetics influence prostate cancer risk and aggressiveness in men, especially among African American populations.
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Genomic factors in prostate cancer among diverse men
A large NIH grant investigates how inherited genes and tumor DNA patterns influence the risk and behavior of prostate cancer, with a focus on diversity in African ancestry men.
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Molecular profiling of about 100,000 genetic variants linked to Mendelian diseases
Scientists will study how about 100,000 genetic variants tied to Mendelian diseases affect cells, helping families understand how these changes may influence health.
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Empowering NMR to Study Proteins More Easily and at Bigger Sizes
A grant to make Nuclear Magnetic Resonance (NMR) studies of proteins faster, more sensitive, and usable for bigger proteins, so researchers can understand how proteins work in health and disease.
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Using blood tests and single-cell epigenetics to detect aggressive changes in prostate cancer
Researchers will use blood-based liquid biopsies and single-cell epigenetic tests to look for early signs that prostate cancer is becoming resistant to hormone treatments in men with advanced disease.
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Illumine: mapping hidden cancer proteins to uncover new treatment paths
A large NIH grant is funding researchers to study the dark proteome—a set of proteins not explained by DNA mutations—to understand their role in cancer and explore new immunotherapy and other treatment approaches.
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Dana-Farber/Harvard Cancer Center ETCTN collaboration (UM1)
A large cancer research collaboration at Dana-Farber and partner Boston hospitals works to advance experimental cancer therapies and biomarker development.
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Why some blood cancer cells survive after treatment by resisting natural killer cells
This work is trying to understand why leftover blood cancer cells in leukemia and multiple myeloma survive treatment by escaping natural killer immune cells.
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Dissecting how liposarcoma cells differentiate and interact with immune cells to find new therapies
This grant explores how liposarcoma cancer cells differentiate and how immune cells in the tumor environment influence progression, with the aim of finding new treatment options for patients.
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Chromatin remodelers in cancer: how mSWI/SNF complexes read the chromatin landscape
Researchers are studying how human cancer cells change their chromatin to drive disease by looking at how mSWI/SNF remodeling proteins read and respond to chemical marks on histones.
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Dynamic BH3 Profiling to Guide Therapy for Relapsed AML
A test called dynamic BH3 profiling will help doctors choose the best treatment for people whose AML has come back or not responded to initial therapy.
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New roles for cell cycle proteins in breast cancer growth and treatment
This NIH grant explores how key cell cycle proteins control cancer cell growth and how targeting them could lead to new breast cancer treatments.
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Understanding how rogue RNA fuels melanoma cancer
This NIH grant supports research to understand how abnormal RNA molecules drive melanoma growth and how this could lead to new cancer treatments.
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Stapled Peptides to Target Cancer Protein Interactions
A cancer-focused grant tests stapled peptide molecules designed to disrupt how cancer proteins talk to each other, aiming to slow or stop tumor growth.
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Advanced tools to spot hereditary cancer risk for patients and families
A new program will improve how we identify patients with hereditary cancer risk so they can get appropriate genetic testing and potentially targeted treatment.
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Healing Gardens: a mobile game-based program to help adults with advanced cancer manage pain
A patient-friendly program uses a playful, phone-based game and coping tools to help adults with advanced cancer reduce pain and use medicines and strategies more effectively.
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TRIM28 Inhibition for NOTCH2-Mutant Small Cell Lung Cancer
A new approach aims to exploit a weakness in a subset of small cell lung cancer by turning on immune-related signals when NOTCH2 is lost, potentially making tumors more visible to the immune system.
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Family-centered risk information and screening education for children with genetic cancer risk
A family-focused, web-based program helps parents and their children understand genetic cancer risk and support regular cancer screening.
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Reprogramming retinoid signals to prevent colorectal cancer progression
A new NIH grant aims to understand how vitamin A signals inside intestinal cells can go awry and drive early cancer-like changes, with the goal of guiding future prevention and treatment ideas.
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Mending aging blood stem cells by boosting their mitochondria
A new approach aims to refresh aging blood-forming stem cells by improving their energy production and mitochondrial function to improve transplant success.
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How macrophage metabolism affects inflammation in tissue sentinels
This grant studies how small molecules inside tissues control tissue-resident macrophages to influence inflammation in diseases like septicemia and metabolic disorders.
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Gene delivery to antigen-specific T cells using targeted retroviral vectors for cancer therapy
A new therapy approach aims to deliver genes directly into cancer-fighting T cells inside the body to empower them to attack tumors.
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Understanding how the RAS/RAF pathway works and how drugs affect it
Researchers are studying the detailed structure and regulation of a key cancer signaling pathway to help design better, more tolerable treatments.
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Bioconductor: An Open-Source Platform for Genomics that Supports Reproducible Science
A long-running, freely available computing resource helps researchers analyze genomic data more reliably and reproducibly with open tools and workflows.
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IN-TACKs: a new way to expose and kill hidden HIV-infected cells
This project develops IN-TACKs, small molecules intended to make hidden HIV-infected cells reveal themselves and die in people living with HIV who are taking antiretroviral therapy.
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ACTIVATE: AI tools to find eligible cancer trial patients in electronic health records
Auburn patient-facing tool helps cancer patients and doctors see if someone might be eligible for a trial using AI to read EHR notes and trial rules.
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Integrative single-cell ideas to map disease genetics
A large NIH grant will use advanced single-cell data to connect genetic clues from GWAS to the biology of complex diseases, with the goal of better understanding how diseases arise in human cells.
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Cross-Training Core for the Next Generation in Radiation Medicine
A program that joins experts across radiation medicine disciplines to build new cross-training, networking, and leadership development for future cancer researchers.
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