Empowering NMR to Study Proteins More Easily and at Bigger Sizes
Official title: Empowering NMR Utilization in Mechanistic Biology: Extending Size Limits and Catalyzing Automation
Funded at Dana-Farber Cancer Inst · NIH-11528496 · Data updated 2026-11-12
A grant to make Nuclear Magnetic Resonance (NMR) studies of proteins faster, more sensitive, and usable for bigger proteins, so researchers can understand how proteins work in health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $94,462 |
| NIH project number | 3R35GM158220-02S1 |
| Project ID | NIH-11528496 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-facing clinical study; applicable to researchers studying disease-relevant proteins using NMR.
✕Less likely to help
No direct patient participation; the grant does not involve clinical trials or patient recruitment.
What this research studies
This project aims to remove barriers that make NMR hard to use for large proteins by developing new methods that extend size limits and boost sensitivity. It also seeks to automate and streamline resonance assignment and data analysis so non-specialists can use NMR more readily. The work will combine methodological advances with practical workflows to shorten measurement times and reduce the need for expert intervention. By improving accessibility, the project could help scientists study disease-relevant proteins more efficiently.
Why it matters
Potential benefit: If successful, patients could benefit from faster research into protein function and interactions, potentially accelerating drug discovery and better understanding of disease mechanisms.
How similar studies have gone: Previous advances in NMR have improved sensitivity and automation, but extending size limits and broadening usability remain active challenges.
Where this research is happening
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Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Arthanari, Haribabu — Dana-Farber Cancer Inst
- Study coordinator: Arthanari, Haribabu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.