How macrophage metabolism affects inflammation in tissue sentinels
Official title: Deciphering the mechanistic basis for metabolite control of macrophages
Funded at Dana-Farber Cancer Inst · NIH-11428489 · Data updated 2026-11-12
This grant studies how small molecules inside tissues control tissue-resident macrophages to influence inflammation in diseases like septicemia and metabolic disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 3, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $416,815 |
| NIH project number | 1R35GM165595-01 |
| Project ID | NIH-11428489 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with chronic inflammatory or metabolic diseases whose tissue environments may be driving macrophage-driven inflammation.
✕Less likely to help
Individuals without inflammatory or metabolic conditions may not directly benefit from the findings.
What this research studies
Researchers will map how local metabolic environments in eight tissues shape tissue-resident macrophages and how these signals drive inflammation in chronic diseases. The project will measure metabolites in interstitial fluid and study macrophages directly within their native tissue contexts to uncover mechanistic links. Findings could reveal new ways to modulate macrophage behavior and reduce harmful inflammation in patients. The work combines advanced metabolomics with in vivo analysis to connect metabolic signals to immune cell responses.
Why it matters
Potential benefit: A deeper understanding of how tissue metabolites control macrophage inflammation could lead to new treatments that lessen chronic inflammatory diseases.
How similar studies have gone: Previous work suggests metabolites influence macrophage function, but this project aims to define exact mechanisms in vivo across multiple tissues.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Mills, Evanna Louisa — Dana-Farber Cancer Inst
- Study coordinator: Mills, Evanna Louisa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.