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Clinical trials and research at Centre for Addiction and Mental Health

• 45Clinical trials
• 10NIH research projects
• 1Country

Newest trials

All recruiting trials (45)

• Youth Master Observational Study of Multiple Mental Health Conditions

  This project follows young people aged 11-24 to see how having two or more mental health conditions develops over time and to learn what factors help or hinder their care.

  Recruiting at 6 sites Centre for Addiction and Mental Health · Calgary, Alberta and 5 other locations · NCT07699159

• Psilocybin-assisted Therapy for people with both major depressive disorder and alcohol use disorder

  This study tests whether psilocybin-assisted therapy can be safely used and help people who have both depression and alcohol use problems.

  Recruiting Phase 2 Centre for Addiction and Mental Health · Toronto, Ontario · NCT07405606

• Role of Psilocybin Monitors in Psilocybin Therapy for Treatment-Resistant Depression

  This study tests whether psilocybin monitors influence the effects of psilocybin therapy in adults with treatment-resistant depression.

  Recruiting at 2 sites Phase 2 Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT07211438

• An EMDR app for PTSD in people with substance dependence.

  This project will test whether an app-based autonomous EMDR program helps adults with PTSD who also have a substance use disorder.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT07146633

• Do antipsychotic drugs block insulin action in the brain?

  This project will test whether haloperidol blocks insulin action in the brain of healthy adults aged 18–35.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT07109245

• THC Titration with High-Potency Cannabis Concentrates

  This study tests whether regular cannabis users can self-titrate the THC dose when vaping concentrates to feel the desired effects.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT07105449

• Theta-burst stimulation for depression

  This trial tests two timing schedules of intermittent theta-burst stimulation (a quick form of TMS) to see which better improves brain plasticity and reduces depressive symptoms in adults 18–50 with major depressive disorder.

  Recruiting Phase 1 Centre for Addiction and Mental Health · Toronto, Ontario · NCT07033780

• Talking for Change — a program to help adults who are worried about sexually offending against children

  This trial will see if a 20-week Talking for Change group psychotherapy helps adults who are concerned about their risk of sexually offending or accessing child sexual exploitation material reduce risk factors and harmful behaviors compared with a general mental-health group or no treatment.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT07001735

• Low-frequency rTMS to the right dorsolateral prefrontal cortex for bipolar depression

  This trial will test whether once-daily low-frequency rTMS to the right DLPFC helps adults with treatment-resistant bipolar depression who did not improve after left-sided iTBS or sham.

  Recruiting at 2 sites Phase 3 Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT06986460

• Using deep brain stimulation to treat severe addiction

  This study is testing if deep brain stimulation can help people with severe addiction who haven't found success with other treatments.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06973512

• Personalized brain stimulation for treating obsessive compulsive disorder

  This study is testing a personalized brain stimulation treatment for obsessive compulsive disorder to see if it works better than a standard version of the same treatment.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06942559

• Digital DBT for Youth at Risk of Psychosis

  This study tests a self-guided digital DBT program to help young people aged 14–35 who are at clinical high risk for psychosis, comparing it to usual care over eight weeks.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06928935

• Using tDCS (mild brain stimulation) to reduce vaping

  This project will try daily transcranial direct current stimulation (tDCS) to reduce cravings and vaping in adults who use nicotine e-cigarettes every day and are not planning to quit.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06885606

• Accelerated versus once-daily theta-burst stimulation for late-life depression

  This test compares multiple theta-burst brain stimulation sessions per day to one session per day to see which better reduces symptoms in people 60 and older with moderate to severe treatment-resistant depression.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT06854367

• Collaborative care program for young adults with Type 1 Diabetes and emotional distress

  This study is testing a new program to see if coaching or education helps young adults with Type 1 Diabetes manage their diabetes and emotional distress better.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06804694

• tDCS plus varenicline to help people quit smoking

  This will test if adding noninvasive tDCS brain stimulation to varenicline helps adults who smoke at least 8 cigarettes a day quit and stay smoke-free.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06798324

• Using brain stimulation to improve memory in people with mild cognitive impairment

  This study is testing if a type of brain stimulation can help improve memory and thinking skills in older adults with mild cognitive impairment.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06783283

• Validating an online cognitive assessment tool for older adults with cognitive issues

  This study is testing an online cognitive assessment tool to see if it can effectively help older adults with mild cognitive impairment or those recovering from depression track their brain health over time.

  Recruiting at 3 sites Centre for Addiction and Mental Health · Toronto, Ontario and 2 other locations · NCT06780917

• Nature-based virtual reality program for depression in Alzheimer's patients

  This study is testing if a nature-based virtual reality program can help reduce depression in people with Alzheimer's disease by providing enjoyable sessions at home.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06732128

• Magnetic seizure therapy versus electroconvulsive therapy for treatment‑resistant schizophrenia

  This trial will test whether magnetic seizure therapy works as well as a specific form of electroconvulsive therapy for adults whose schizophrenia or schizoaffective disorder has not improved with medications.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Vancouver, British Columbia and 1 other locations · NCT06672588

• Deep TMS to help adults with psychiatric conditions quit smoking

  This project will test whether deep transcranial magnetic stimulation (dTMS) helps adults with psychiatric disorders quit smoking better than usual nicotine replacement and counseling.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06534047

• Using psilocybin to treat chronic pain and depression

  This study is testing if psilocybin therapy can help adults with chronic pain and depression feel better when combined with therapy.

  Recruiting Phase 2 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06518720

• Exploring how psilocybin affects brain synapses in patients with treatment-resistant depression

  This study is testing if psilocybin can change brain connections in adults with treatment-resistant depression to see if it helps improve their symptoms.

  Recruiting Phase 2 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06512220

• Using rTMS to enhance motor function in autistic adults

  This study is testing if a brain treatment called rTMS can help improve motor skills in autistic adults who have trouble with movement.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06497920

• Personalized treatment for children with disruptive behavior and their parents

  This study is testing a personalized treatment approach for children aged 6-12 with disruptive behavior and their parents to see if it can improve the effectiveness of therapy.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06373484

• Using theta-burst stimulation to treat bipolar depression

  This study is testing if a new brain stimulation technique can help people with bipolar disorder who haven't found relief from their depression.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT06370988

• Using magnetic stimulation to help people quit smoking

  This study is testing if a new type of brain stimulation can help daily smokers quit smoking by making it easier for them to stop.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06346028

• Imaging brain activity in patients with depression after COVID-19

  This study is trying to see how COVID-19 might affect brain activity in people who have depression after their infection.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT06086366

• Using magnetic stimulation to treat cannabis use disorder

  This study is testing if a new treatment using magnetic stimulation can help people with cannabis use disorder reduce their cannabis consumption and improve their overall well-being.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05859347

• Assessing Patients with Alcohol and Cannabis Use Disorders

  This study is testing how a 12-week therapy program can help people with alcohol and cannabis use disorders by looking at how their thinking and feelings before treatment relate to their progress during therapy.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05855668

• Using Metformin to Manage Weight Gain from Antipsychotics in Adults with Intellectual Disabilities

  This study tests if Metformin can help adults with intellectual disabilities who are gaining weight from antipsychotic medications lose weight and improve their health.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT05744479

• Booster sessions of Dialectical Behavior Therapy for youth at risk for bipolar disorder

  This study is testing if extra Dialectical Behavior Therapy sessions can help young people who are at risk for bipolar disorder stay on track after finishing a full year of therapy.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05627492

• Personalized brain stimulation for treatment-resistant depression

  This study is testing if a personalized brain stimulation treatment can help people with treatment-resistant depression feel better compared to standard methods.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT05583747

• Effects of cannabis and tobacco on driving and cognition

  This study tests how smoking or vaping cannabis and tobacco affects driving skills and thinking abilities in adults who use both substances.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05526196

• Impact of Menstrual Cycle Phase on Smoking Cessation

  This study tests if starting smoking cessation treatment during certain phases of the menstrual cycle helps women quit smoking more successfully.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT05515354

• Dialectical behavior therapy for youth at risk for bipolar disorder

  This study is testing if dialectical behavior therapy can help young people aged 13 to 23 who are at risk for bipolar disorder learn important skills to manage their emotions and relationships.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05153382

• DBT-informed care for youth with bipolar disorder

  This study is testing a new way to help young people with bipolar disorder by using different levels of therapy based on their individual needs to see if it improves their emotional health and safety.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05153369

• N-acetylcysteine effects on early symptoms of schizophrenia

  This study is testing if a supplement called N-acetylcysteine can help people at high risk for schizophrenia feel better by reducing early symptoms over 8 weeks.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05142735

• Evaluating an Integrated Care Pathway for treating adolescent depression

  This study is testing a new treatment approach for teens aged 13 to 18 with depression to see if it helps them feel better compared to the usual care they receive.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05142683

• Using rTMS to treat depression in young adults with autism

  This study is testing if a new brain stimulation treatment can help young adults with autism and depression feel better.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT04972136

• Effects of stopping cannabis use on depression and cognition

  This study is testing if stopping cannabis use for 28 days can help people with depression and cannabis addiction feel better and think more clearly.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT04935619

• Alternate day dosing of antipsychotics for schizophrenia

  This study tests if taking antipsychotic medications every other day instead of every day can help people with schizophrenia feel better while experiencing fewer side effects.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT04478838

• Understanding and Modifying Perceptual Distortions in Body Dysmorphic Disorder

  This study is testing if new visual techniques can help change the way people with body dysmorphic disorder see themselves and their appearance.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT04373629

• Effects of cannabis on driving in young versus middle-aged users

  This study tests how smoking cannabis affects the driving skills of young and middle-aged people by comparing their performance in a driving simulator.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT04325958

• Switching clozapine dosing from twice daily to once daily for schizophrenia

  This study is testing if switching people with schizophrenia from taking clozapine twice a day to once a day can still be effective and easier for them to manage.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT02639702

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biomarkers to Guide Early Treatment in First-Episode Psychosis (BEEST)

  A multi-center study aims to use brain scans and genetic information to help teens and young adults with a first episode of psychosis choose the best antipsychotic sooner.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-11405513

• Using biomarkers to guide early schizophrenia care

  This project uses brain scans and simple genetic tests to help doctors decide sooner if young people (ages 12–20) with a first episode of psychosis should switch to clozapine.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-11184377

• Understanding how people use high-potency cannabis concentrates

  This project looks at how regular cannabis users adjust their dose when using strong cannabis concentrates and what effects these products have on their body and mind.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-11131146

• Using biomarkers to improve treatment decisions for early schizophrenia

  This study is looking to help young people who are experiencing their first episode of psychosis by creating a tool that uses brain scans and genetic tests to find out which treatments will work best for them, so they can get the right help with fewer side effects.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-10979543

• Investigating how regular cannabis users adjust their THC intake with different potency concentrates

  This study is looking at how people who regularly use cannabis can control their THC intake when using strong cannabis concentrates, by having them try different levels of THC to see how it affects their experience and body.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-10951596

• Investigating the genetic links between substance use and psychiatric disorders

  This study is looking at how tobacco addiction and mental health issues like schizophrenia might be linked through shared genetics, with the hope of finding new ways to improve treatment for people dealing with both challenges.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-10918045

• Understanding how alcohol control can improve health and life expectancy in the US

  This study looks at how drinking alcohol affects how long people live in the U.S., especially considering factors like income and race, and aims to find ways to reduce alcohol-related deaths and improve health for everyone.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-10893466

• Understanding and changing how the brain sees appearance in body dysmorphic disorder

  This project explores how the brains of people with body dysmorphic disorder process visual information about their appearance, hoping to find ways to help them see themselves more accurately.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-10857174

• Impact of alcohol control policies on health outcomes in the Baltic states

  This study looks at how new rules in Lithuania about alcohol, like higher taxes and fewer ads, are helping to improve health by reducing hospital visits and deaths from drinking too much, and it compares these results with neighboring countries to see how well these changes are working.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-10817750

• Understanding how to change visual perception in people with body dysmorphic disorder

  This study is looking at how people with body dysmorphic disorder see themselves and is trying to find new ways to help change those thoughts, using brain imaging and other techniques to understand how their minds work.

  NIH research Centre for Addiction and Mental Health · Toronto, Canada · NIH-10655303

Quick answers

How many clinical trials run by Centre for Addiction and Mental Health are recruiting right now?

45, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in Canada. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 8, Phase 2: 4, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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