Investigating how regular cannabis users adjust their THC intake with different potency concentrates
THC titration of high-potency cannabis concentrates: A randomized crossover trial
This study is looking at how people who regularly use cannabis can control their THC intake when using strong cannabis concentrates, by having them try different levels of THC to see how it affects their experience and body.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Centre for Addiction and Mental Health NIH-funded |
| Lab location | 1 site (Toronto, Canada) |
| Project ID | NIH-10951596 on NIH RePORTER |
What this research studies
This research examines how regular cannabis consumers manage their THC intake when using high-potency cannabis concentrates. Participants will be involved in a randomized crossover trial where they will vape concentrates with varying THC levels (30%, 60%, and 90%) to assess their ability to self-titrate the dosage for desired effects. The study will also evaluate the subjective experiences, cognitive effects, and physiological responses associated with different THC potencies. Conducted in Toronto, Canada, this research aims to provide insights into the safety and regulation of high-potency cannabis products.
Who could benefit from this research
Good fit: Ideal candidates for this research are regular cannabis consumers who are familiar with using cannabis concentrates.
Not a fit: Patients who do not use cannabis or have no experience with cannabis concentrates may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help inform safer consumption practices and regulatory policies for high-potency cannabis products.
How similar studies have performed: While there is limited evidence on self-titration in high-potency cannabis use, this approach is novel and aims to fill gaps in current understanding.
Where this research is happening
Toronto, Canada
- Centre for Addiction and Mental Health — Toronto, Canada (Active)
Researchers
- Principal investigator: Rueda, Sergio — Centre for Addiction and Mental Health
- Study coordinator: Rueda, Sergio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.