Investigating how regular cannabis users adjust their THC intake with different potency concentrates
Official title: THC titration of high-potency cannabis concentrates: A randomized crossover trial
Funded at Centre for Addiction and Mental Health · NIH-10951596 · Data updated 2026-11-12
This study is looking at how people who regularly use cannabis can control their THC intake when using strong cannabis concentrates, by having them try different levels of THC to see how it affects their experience and body.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Centre for Addiction and Mental Health NIH-funded |
| Lab location | 1 site (Toronto, Canada) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $143,492 |
| NIH project number | 1R21DA061350-01 |
| Project ID | NIH-10951596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are regular cannabis consumers who are familiar with using cannabis concentrates.
✕Less likely to help
Patients who do not use cannabis or have no experience with cannabis concentrates may not benefit from this research.
What this research studies
This research examines how regular cannabis consumers manage their THC intake when using high-potency cannabis concentrates. Participants will be involved in a randomized crossover trial where they will vape concentrates with varying THC levels (30%, 60%, and 90%) to assess their ability to self-titrate the dosage for desired effects. The study will also evaluate the subjective experiences, cognitive effects, and physiological responses associated with different THC potencies. Conducted in Toronto, Canada, this research aims to provide insights into the safety and regulation of high-potency cannabis products.
Why it matters
Potential benefit: If successful, this research could help inform safer consumption practices and regulatory policies for high-potency cannabis products.
How similar studies have gone: While there is limited evidence on self-titration in high-potency cannabis use, this approach is novel and aims to fill gaps in current understanding.
Where this research is happening
-
Centre for Addiction and Mental Health
Toronto, Canada Active
Researchers
- Principal investigator: Rueda, Sergio — Centre for Addiction and Mental Health
- Study coordinator: Rueda, Sergio
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.