Sponsor or institution
Clinical trials and research at California Institute of Technology
As of November 12, 2026, Find a Trial lists 1 clinical trial run by California Institute of Technology that is recruiting, in United States. There are also 159 NIH-funded research projects at this institution, with $126.7 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 1Clinical trials
- 159NIH research projects
- 1Country
All recruiting trials (1)
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Brain-controlled prosthetic communication for paralyzed individuals
This study is testing a brain-chip that helps people with severe paralysis control a computer directly with their thoughts to see if it can improve their ability to communicate.
NIH-funded research (newest 40 of 159)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Genetic and Neural Drivers of Sleep in Zebrafish
Researchers are studying how genes and brain signals control sleep using zebrafish to understand why sleep disorders happen and how to treat them.
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Wireless, skin-friendly neck wearable to support voice/airway care
A neck-worn, wireless sensor system combines two measurements to help people with voice and airway problems manage symptoms and stay adherent to treatment.
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Bacterial gene activity in human tissues to link microbes and host health
A research project to map which genes are active in both human tissues and their resident bacteria to better understand conditions like Crohn’s disease.
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In Situ Amplification for Biological Imaging using Hybridization Chain Reaction
A research grant supporting a new imaging approach that helps scientists visualize where RNA and proteins are located inside tissues and embryos.
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WormBase: a life science data hub for C. elegans and other nematodes
Aimed at continuously improving WormBase, a key online data resource used by researchers studying C. elegans and related nematodes, to help scientists access genome and gene information more efficiently.
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Alliance Central: A platform to build smarter genome knowledge bases
A NIH-funded project to create a next-generation software platform and data framework that helps scientists integrate and harmonize genome and model-organism data to better understand human health and disease.
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Minimally invasive blood‑vessel brain sensors for recording and stimulating brain activity
A team is developing tiny, flexible brain sensors that can be threaded through blood vessels to record and stimulate brain activity for people with Alzheimer's, acquired brain injury, and other neurological disorders.
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Neural control of everyday actions in the human brain
A research project at Caltech is exploring how the brain coordinates everyday tasks like making breakfast or driving, and how rapid decisions and actions emerge from brain activity.
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Comprehensive protein detectors for the human proteome
A big new project to create many highly specific protein-binding tools (nanobodies) so scientists can reliably study most human proteins.
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How flies find food by quick turns and sensing the wind
Researchers are studying how fruit flies use fast directional turns and wind information to search for food, which could inform how brains guide movement in uncertain environments.
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Targeted brain-delivery AAV toolkit for cell-type specific gene expression
This NIH grant aims to create a toolkit of engineered AAVs to deliver genes to specific brain cell types in rodents and non-human primates, improving delivery across the blood-brain barrier.
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Targeting cancer signaling at the protein-membrane interface
This NIH grant aims to develop new ways to block the way cancer-related proteins interact with cell membranes, potentially slowing or stopping cancer signaling for patients.
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Uric acid skin sensor to guide gout treatment and diet
A skin patch that measures uric acid in sweat is being tested to help people with gout manage their diet and medications better.
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Wireless, skin‑friendly neck wearable for voice and airway health
A neck-worn, wireless wearable will track voice and upper airway health using two sensing modes to help people with airway conditions improve treatment adherence.
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Wearable skin patch that tracks uric acid and metabolites for people with gout
A wearable skin patch will measure uric acid and other metabolites around meals to help people with gout make better diet and medication choices.
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Molecular clues behind how fetal and adult T cells develop differently
This grant looks at why T cells formed before birth behave differently from those formed after birth, using human samples and advanced chromatin analysis.
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Tailor-Made Molecular Helpers to Stop Protein Misfolding in Alzheimer’s
Researchers are developing customized molecular chaperones to prevent harmful protein clumps that contribute to Alzheimer’s disease and related dementias, with tests in cells and animal models.
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Mechanistic details of key membrane enzymes for antimicrobial discovery
A research project at Caltech aims to uncover how two bacterial enzymes work and how to block them with new medicines for infections.
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Bidirectional signaling by FGFs in developmental biology
Researchers are studying how fibroblast growth factor proteins may signal both outside and inside cells, using a fruit-fly model to understand how this could affect development and cell behavior.
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Region-specific, controllable tracing of brain axons to study how neural networks shape behavior
This NIH grant funds research to develop and use advanced genetic tools to map and control specific brain neuron groups that influence affective and social behaviors.
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How early embryos self-organize into a protective, layered structure
This research looks at how mammalian embryos naturally form an organized, two-layer structure by the 16-cell stage, helping us understand early development and potential improvements in assisted reproduction.
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Early-Stage Tech to Measure Fungal Activity in Vaginal Samples
A small NIH-funded project aims to develop a new method to reliably measure fungal activity directly in vaginal samples from people with fungal infections.
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Understanding how mitochondria stay healthy in brain cells
A project at Caltech studies how mitochondria in brain-supporting cells keep their power plants balanced and healthy, which could help prevent neuron damage.
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Viral MEM: Precise, contamination-free virome analysis for challenging human samples
A new, highly accurate method set aims to reveal all viruses in difficult human tissue samples by removing human DNA and other noise.
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How some enzymes handle oxygen safely
This project studies how important oxygen-using enzymes stay active and safe from harmful reactive molecules in the body.
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Understanding how Pseudomonas aeruginosa manages its power and survives in burns and wounds
This NIH grant explores how the bacteria Pseudomonas aeruginosa use a molecule called pyocyanin to support biofilm growth and antibiotic tolerance in burn injuries and related infections.
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New Insights into How Cells Repair Damaged DNA During Replication
A scientist-led project at Caltech is exploring how cells fix dangerous DNA damage that happens when DNA is copied, which is important for preventing cancer and aging.
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Promoter-proximal elements coordinating gene control in development
This NIH grant explores how gene activity is tuned in specific tissues and times by promoter-proximal elements that help long-range DNA regions talk to the gene’s start signal.
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Molecular basis of how mRNA gets from the nucleus to the rest of the cell
A study to understand how messenger RNA is exported from the cell nucleus through the nuclear pore complex, which could inform diseases where cellular transport goes wrong.
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Superchanneling, Caspase Regulation, and RNA Control in Ubiquitin-Proteasome Pathways
A long-running NIH grant studies how the ubiquitin-proteasome system controls protein breakdown and RNA stability, with implications for cancer, neurodegeneration, and immunity, to understand new ways to influence health.
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Synthesis methods to make chiral bioactive molecules for cancer medicines
Aims to develop new ways to build complex, chiral molecules that could become cancer-fighting drugs.
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How beetles and ants evolved to work together
Researchers study how beetles that live with ants developed specialized chemistry and behavior that ties them to ants, which could reveal ways to understand and treat symbiotic relationships in humans.
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Principles of Regulation, Change, and Adaptation in Cells and Populations
This NIH grant explores how cells and microbial populations regulate genes and adapt to different environments, with a focus on gut bacteria like E. coli and pathogens such as Pseudomonas aeruginosa.
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Understanding brain sugar patterns to support memory and healing
A research project aims to uncover how brain sugar molecules called chondroitin sulfate glycosaminoglycans influence brain plasticity, memory, and repair, with potential implications for Alzheimer’s disease.
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How tail-region nerve cells help form nerves in the lower gut
Researchers are tracing how nerve cells that come from the tail region build the lower gut's nervous system to help people with congenital gut nerve problems like Hirschsprung disease.
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Enantioselective, metal-catalyzed joining of alkyl pieces to build complex molecules
A research grant exploring new copper/nickel-catalyzed methods to join alkyl pieces into larger, chiral organic molecules that could be useful in biomedical research.
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Understanding how fear and anxiety work in the human brain
A research project at Caltech is studying how the brain and body respond to different levels of threat to better understand fear and anxiety in people.
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Predicting psychiatric symptoms from brain-based learning patterns
This grant will study how differences in learning and decision-making patterns, measured with computer tasks, relate to anxiety and other psychiatric symptoms over time.
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Understanding sex differences in kidney health
This work explores why men and women might experience kidney injury and chronic kidney disease differently.
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How gut nerve cells choose their roles during development
Researchers are mapping how gut nerve cells form and testing genes that guide their development to help people with conditions like Hirschsprung's disease.
Quick answers
How many clinical trials run by California Institute of Technology are recruiting right now?
1, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.