Promoter-proximal elements coordinating gene control in development
Official title: Regulation of long distance enhancer-promoter interactions by promoter-proximal elements
Funded at California Institute of Technology · NIH-11350920 · Data updated 2026-11-12
This NIH grant explores how gene activity is tuned in specific tissues and times by promoter-proximal elements that help long-range DNA regions talk to the gene’s start signal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | August 19, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $362,060 |
| NIH project number | 5R01HD106799-05 |
| Project ID | NIH-11350920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; basic research using model organisms to understand gene regulation.
✕Less likely to help
No direct patient participation or clinical testing in this phase.
What this research studies
This project studies how regions outside a gene, called enhancers, communicate with the gene’s promoter to control when and where a gene is turned on during development. Using the fruit fly as a model, researchers will examine a promoter-proximal element that seems to coordinate multiple regulatory regions and long-range DNA interactions. The work combines genetics, molecular biology, and chromatin studies to uncover how these interactions shape normal development and tissue maintenance. Findings could illuminate fundamental mechanisms that, when disrupted, lead to developmental disorders.
Why it matters
Potential benefit: Better understanding of how gene regulation goes wrong could inform treatments or prevention strategies for diseases linked to developmental gene control.
How similar studies have gone: Prior work in model organisms suggests promoter-proximal elements can coordinate enhancer activity, supporting the potential for broader applicability.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Stathopoulos, Angelike — California Institute of Technology
- Study coordinator: Stathopoulos, Angelike
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.