Comprehensive protein detectors for the human proteome
Official title: Generation of comprehensive protein affinity reagents for the human proteome
Funded at California Institute of Technology · NIH-11405549 · Data updated 2026-11-12
A big new project to create many highly specific protein-binding tools (nanobodies) so scientists can reliably study most human proteins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,119,634 |
| NIH project number | 1R01CA325352-01 |
| Project ID | NIH-11405549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and clinicians studying any human disease could benefit from improved protein detection reagents to advance diagnostics and treatments.
✕Less likely to help
Direct patient benefit may be limited until translated into diagnostics or therapies; initial work is laboratory-based.
What this research studies
This project aims to build a scalable platform to generate and validate nanobodies that bind to a wide range of human proteins. It proposes a novel RAMEN approach using split-and-pool barcoding to ensure both large scale and high specificity. By providing validated reagents for many proteins, it could streamline diagnostic and therapeutic development and advance basic biology. The work will involve protein targets, assay development, and rigorous validation to ensure reproducibility across studies.
Why it matters
Potential benefit: If successful, patients could benefit from faster development of precise diagnostics and targeted therapies driven by better protein detection tools.
How similar studies have gone: Previous efforts improved antibodies but struggled with scale and specificity; this project proposes a novel, scalable solution that is still being tested.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Guttman, Mitchell — California Institute of Technology
- Study coordinator: Guttman, Mitchell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.