Alliance Central: A platform to build smarter genome knowledge bases
Official title: Alliance Central: A platform for sustainable development of next generation genome knowledgebases
Funded at California Institute of Technology · NIH-11418430 · Data updated 2026-11-12
A NIH-funded project to create a next-generation software platform and data framework that helps scientists integrate and harmonize genome and model-organism data to better understand human health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | September 18, 2019 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $4,859,241 |
| NIH project number | 5U24HG010859-08 |
| Project ID | NIH-11418430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a direct patient study; the project enables research that may inform patient-centered discoveries.
✕Less likely to help
Patients will not participate in this project as subjects.
What this research studies
This grant supports developing a flexible software platform and standardized data models to coordinate curation and sharing of genetic and genomic information from model organisms and humans. It involves collaboration among model-organism databases and the Gene Ontology Consortium to create integrated knowledge bases. The goal is to make it easier for researchers, clinicians, and data scientists to access reliable, up-to-date annotations and insights that connect model organism biology to human health. The work combines software development, data curation, and community standards to enable scalable, interoperable knowledge resources.
Why it matters
Potential benefit: If successful, patients could benefit from faster translation of basic biology into understanding human diseases and identifying potential therapeutic targets.
How similar studies have gone: Previous model organism knowledgebases and data-sharing platforms have shown that standardized, interoperable data accelerate discovery.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Sternberg, Paul Warren — California Institute of Technology
- Study coordinator: Sternberg, Paul Warren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.