XenCAT: Single Cell Atlas for Xenopus
Official title: XenCAT: Xenopus Single Cell Atlas
Funded at Beth Israel Deaconess Medical Center · NIH-11594482 · Data updated 2026-11-12
Aims to map gene activity at the single-cell level in Xenopus to help understand how cells develop and how this relates to human disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 14, 2026 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $691,785 |
| NIH project number | 7R24OD031956-05 |
| Project ID | NIH-11594482 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and clinicians who study human diseases may benefit from the cross-species cellular insights the atlas provides.
✕Less likely to help
Patients are unlikely to be directly involved or immediately benefit from the project.
What this research studies
This project will build a cell-by-cell map of gene activity in the Xenopus model to study how cells organize themselves during development. By creating a single-cell atlas and comparing it with other species, researchers hope to reveal how cellular programs go awry in disease and how predictable models can be built for therapy testing. The work involves advanced sequencing, data integration, and collaboration with model-organism and human genomics researchers to interpret functional cell networks. The atlas will serve as a resource for scientists to explore how genes work together across contexts that resemble human biology. Outcomes may inform better disease models and potential therapeutic strategies in the future.
Why it matters
Potential benefit: If successful, the atlas could accelerate understanding of how cell-level gene networks contribute to human diseases and improve disease modeling.
How similar studies have gone: Other single-cell atlases in model organisms have improved our understanding of development and disease; Xenopus-specific atlas work is an expansion of this approach.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Peshkin, Leon — Beth Israel Deaconess Medical Center
- Study coordinator: Peshkin, Leon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.