Statin use after lobar brain hemorrhage
StATins Use in intRacerebral hemorrhage patieNts (SATURN)
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11518525 on NIH RePORTER |
What this research studies
If you had a lobar intracerebral hemorrhage and were taking a statin, this multi-center trial would randomly assign you to stop or continue your statin medication. The trial is pragmatic and open-label, but outcomes like recurrent symptomatic brain bleeding and major heart or stroke events are judged by blinded reviewers. Participants are followed for about 24 months with clinical visits, imaging (MRI for microbleeds), and genetic testing for APOE to understand who may be at higher risk. The study also tracks functional recovery, cognitive outcomes, and quality of life over time.
Who could benefit from this research
Good fit: Ideal candidates are adults who had a lobar intracerebral hemorrhage and were taking a statin at the time of the bleed and are stable enough to be randomized.
Not a fit: People who did not have a lobar ICH, who were not taking statins, or who are medically unstable likely would not benefit from joining this trial.
Why it matters
Potential benefit: If successful, the trial could clarify whether continuing or stopping statins lowers the chance of repeat brain bleeding without increasing heart or stroke complications.
How similar studies have performed: Observational studies have suggested a possible link between statins and increased ICH risk in lobar ICH and in APOE ε2/ε4 carriers, but there have been no prior randomized trials directly comparing continuation versus stopping, so this question remains largely untested in randomized fashion.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.