Statin use after lobar intracerebral hemorrhage
StATins Use in intRacerebral hemorrhage patieNts (SATURN)
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11518526 on NIH RePORTER |
What this research studies
If you had a lobar intracerebral hemorrhage (a type of brain bleed) and were taking a statin, you could be randomly assigned to either continue or stop your statin medication. The trial is run at multiple centers and uses an open-label design with blinded outcome review, and follows participants for about 24 months. Researchers will track repeat symptomatic ICH, major vascular events (like ischemic stroke or heart attack), functional and cognitive outcomes, and quality of life. The study will also consider factors such as APOE genotype and brain microbleeds on MRI when interpreting results.
Who could benefit from this research
Good fit: Adults who suffered a lobar intracerebral hemorrhage and were taking a statin at the time of the bleed are the ideal candidates.
Not a fit: People with non-lobar ICH, those not on statins, or patients with medical reasons preventing statin changes are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the trial could clarify whether keeping or stopping statins after lobar ICH lowers the chance of another brain bleed without raising heart-related risks.
How similar studies have performed: There are no prior randomized trials addressing this question; observational data suggest a small link between statins and ICH risk in lobar ICH, so this randomized approach is relatively novel.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Selim, Magdy H — Beth Israel Deaconess Medical Center
- Study coordinator: Selim, Magdy H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.