Vascular factors and genetic risks in Alzheimer’s disease
Official title: Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease
Funded at University of Southern California · NIH-11377196 · Data updated 2026-11-12
A large NIH grant is exploring how blood vessel health and genetic risk, including APOE variants, influence Alzheimer’s disease and its early cognitive changes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 30, 2016 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $3,223,331 |
| NIH project number | 5P01AG052350-09 |
| Project ID | NIH-11377196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people at risk for or showing early cognitive changes associated with Alzheimer’s disease, especially with APOE risk factors.
✕Less likely to help
There may be no direct benefit for healthy individuals or those outside the study focus who do not have or are not at risk for AD.
What this research studies
This program brings many researchers from USC and partner institutions to study whether problems in brain blood vessels contribute to dementia and how genetic risk factors shape this process. It uses imaging, biomarkers, and data from multiple projects and cores to understand early brain changes in AD. The goal is to identify new targets for preventing or slowing cognitive decline linked to vascular health and genetics. The work builds on years of data and collaboration to test the neurovascular hypothesis of Alzheimer’s disease.
Why it matters
Potential benefit: If successful, findings could lead to new prevention or treatment strategies that target brain blood vessels and genetic risk factors.
How similar studies have gone: Previous work in this area has shown promise in linking vascular health and genetic risk to cognitive decline, but this program aims for broader, multi-center validation.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Toga, Arthur W — University of Southern California
- Study coordinator: Toga, Arthur W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.