Understanding blood clot risks after procedures for kidney disease
Official title: Disease-specific risk factors for thrombosis following vascular interventions
Funded at Boston Medical Center · NIH-11142435 · Data updated 2026-11-12
This work explores why people with chronic kidney disease are more likely to develop blood clots after medical procedures, aiming to find new ways to prevent them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $678,195 |
| NIH project number | 5R01HL166608-03 |
| Project ID | NIH-11142435 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for patients with chronic kidney disease who are at risk for or have undergone vascular interventions.
✕Less likely to help
Patients without chronic kidney disease or those not undergoing vascular interventions may not directly benefit from this specific research.
What this research studies
Patients with chronic kidney disease (CKD) often need procedures like angioplasty or vascular surgery, but they face a higher risk of dangerous blood clots afterward. This project aims to understand the specific factors in CKD that contribute to this increased clotting risk. We are looking at certain substances that build up in the blood of CKD patients, like indoxyl sulfate and kynurenine, to see how they might cause blood vessels to form clots. By uncovering these mechanisms, we hope to identify new targets for treatments that could protect CKD patients from these serious complications.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent dangerous blood clots in patients with chronic kidney disease who undergo vascular interventions.
How similar studies have gone: Previous work by this team has shown that certain uremic toxins can promote blood clotting, providing a foundation for this current investigation.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Chitalia, Vipul C — Boston Medical Center
- Study coordinator: Chitalia, Vipul C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.