Investigating risk factors for blood clots after vascular procedures in kidney disease patients
Official title: Disease-specific risk factors for thrombosis following vascular interventions
Funded at Boston Medical Center · NIH-10898052 · Data updated 2026-11-12
This study is looking at how certain substances in the blood might increase the risk of blood clots in people with chronic kidney disease who need vascular treatments, with the hope of finding ways to make these procedures safer and more effective for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $661,143 |
| NIH project number | 5R01HL166608-02 |
| Project ID | NIH-10898052 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease who are scheduled for vascular procedures.
✕Less likely to help
Patients without chronic kidney disease or those not requiring vascular interventions may not benefit from this research.
What this research studies
This research focuses on understanding the specific risk factors that contribute to blood clot formation in patients with chronic kidney disease (CKD) who undergo vascular interventions. By examining the effects of certain uremic solutes, such as indoxyl sulfate and kynurenine, the study aims to uncover how these substances influence thrombosis risk. The research employs both human and animal models to explore the mechanisms behind these risks and seeks to identify potential therapeutic targets to improve patient outcomes. Ultimately, the goal is to enhance the safety and effectiveness of vascular procedures for CKD patients.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing blood clots in patients with chronic kidney disease undergoing vascular interventions.
How similar studies have gone: Previous research has indicated that targeting uremic solutes may provide insights into managing thrombosis in CKD, suggesting a promising avenue for this investigation.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Chitalia, Vipul C — Boston Medical Center
- Study coordinator: Chitalia, Vipul C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.