Investigating risk factors for blood clots after vascular procedures in kidney disease patients
Disease-specific risk factors for thrombosis following vascular interventions
['FUNDING_R01'] · BOSTON MEDICAL CENTER · NIH-10898052
This study is looking at how certain substances in the blood might increase the risk of blood clots in people with chronic kidney disease who need vascular treatments, with the hope of finding ways to make these procedures safer and more effective for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10898052 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the specific risk factors that contribute to blood clot formation in patients with chronic kidney disease (CKD) who undergo vascular interventions. By examining the effects of certain uremic solutes, such as indoxyl sulfate and kynurenine, the study aims to uncover how these substances influence thrombosis risk. The research employs both human and animal models to explore the mechanisms behind these risks and seeks to identify potential therapeutic targets to improve patient outcomes. Ultimately, the goal is to enhance the safety and effectiveness of vascular procedures for CKD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease who are scheduled for vascular procedures.
Not a fit: Patients without chronic kidney disease or those not requiring vascular interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing blood clots in patients with chronic kidney disease undergoing vascular interventions.
How similar studies have performed: Previous research has indicated that targeting uremic solutes may provide insights into managing thrombosis in CKD, suggesting a promising avenue for this investigation.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHITALIA, VIPUL C — BOSTON MEDICAL CENTER
- Study coordinator: CHITALIA, VIPUL C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.