Understanding long-term lung problems after TB treatment and who’s at risk in Peru
Official title: Host- and pathogen-specific risk factors for post-tuberculosis lung disease among people successfully treated for TB in Lima, Peru: Beat-PTLD
Funded at Harvard Medical School · NIH-11418869 · Data updated 2026-11-12
This study looks at people who were successfully treated for TB in Lima, Peru, to see how common long-lasting lung problems are and who is most at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $347,575 |
| NIH project number | 5R01HL178712-02 |
| Project ID | NIH-11418869 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who completed TB treatment in Lima, Peru, and healthy community controls.
✕Less likely to help
Individuals without prior TB or without long-term lung symptoms may have little direct benefit.
What this research studies
Researchers will re-examine 1,000 people who completed TB treatment and 291 community controls to measure lung function 2–3 years after diagnosis. They will use existing cohort data to identify patterns of post-TB lung disease, including obstruction, restriction, and other lung issues, plus factors that may increase risk. The goal is to find who is most at risk and how best to screen for PTLD so that care can be better targeted after TB treatment. The study position emphasizes patient health and real-world relevance by focusing on outcomes that affect daily breathing and quality of life in those who survived TB.
Why it matters
Potential benefit: If successful, the research could lead to better screening and interventions to prevent or lessen long-term lung damage after TB.
How similar studies have gone: Prior work indicates substantial PTLD burden; this study builds on known associations with a strong, real-world cohort.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Mitnick, Carole D. — Harvard Medical School
- Study coordinator: Mitnick, Carole D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.