Understanding how immune cells produce inflammatory signals in children with arthritis

Who could benefit from this research

What this research studies

This research investigates the mechanisms behind the production of inflammatory cytokines, specifically interferon gamma (IFNγ) and interleukin-17 (IL-17), by T helper cells in children suffering from juvenile idiopathic arthritis (JIA). The study aims to identify genetic mutations that may lead to abnormal immune responses in these patients. By examining how these immune cells develop and function, the research seeks to uncover potential biological markers that could enhance diagnosis and treatment options for JIA. The findings could provide insights into the underlying causes of chronic joint inflammation in affected children.

Why it matters

Where this research is happening

• Vanderbilt University Medical Center
  Nashville, United States Active

Researchers

• Principal investigator: Patrick, Anna Elizabeth — Vanderbilt University Medical Center
• Study coordinator: Patrick, Anna Elizabeth

Related research

Other NIH-funded projects on the same topics.

• Deciphering What Drives Juvenile Idiopathic Arthritis in African American Children

  This project looks at why African American children with juvenile idiopathic arthritis have more joint damage, using clinical data and genetic information to find factors that may explain the differences.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11442239

• Understanding how T cells make IFN-γ and IL-17 in kids with juvenile arthritis

  A doctor-scientist at Vanderbilt is studying why certain immune cells in children with juvenile idiopathic arthritis produce inflammatory signals, with the goal of improving diagnosis and treatment.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11392245

• Lung disease linked to systemic juvenile idiopathic arthritis in children

  This project looks at how ongoing immune activation and some arthritis medicines may cause lung inflammation and breathing problems in children with systemic juvenile idiopathic arthritis (SJIA).

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11326213

• Linking JIA Registry with Claims Data to Improve Understanding of Juvenile Arthritis

  A study will connect the CARRA JIA patient registry with a large national claims database to see how well registry data match real-world care and outcomes for children with juvenile idiopathic arthritis.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11295916

• Investigating the role of viruses and gut bacteria in arthritis flares in children

  This study is looking at how certain viruses and bacteria in the gut might affect flare-ups of juvenile idiopathic arthritis in kids, hoping to find clues that could help manage these painful episodes better.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11056288

• Understanding lung disease in children with systemic juvenile idiopathic arthritis

  This study is looking at how a serious lung problem in some kids with systemic juvenile idiopathic arthritis happens, and it aims to find new ways to help treat or prevent this issue by understanding how a certain part of their immune system works.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11042812

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.