Understanding how immune cells produce inflammatory signals in children with arthritis
Mechanisms of T Cell IFNy and IL-17 Production in Juvenile Idiopathic Arthritis
This study is looking at how certain immune cells in children with juvenile idiopathic arthritis produce substances that cause inflammation, and it hopes to find genetic clues that could help improve how we diagnose and treat this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10903950 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the production of inflammatory cytokines, specifically interferon gamma (IFNγ) and interleukin-17 (IL-17), by T helper cells in children suffering from juvenile idiopathic arthritis (JIA). The study aims to identify genetic mutations that may lead to abnormal immune responses in these patients. By examining how these immune cells develop and function, the research seeks to uncover potential biological markers that could enhance diagnosis and treatment options for JIA. The findings could provide insights into the underlying causes of chronic joint inflammation in affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with juvenile idiopathic arthritis.
Not a fit: Patients with juvenile idiopathic arthritis who do not have significant inflammatory responses or those outside the age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for children with juvenile idiopathic arthritis.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Patrick, Anna Elizabeth — Vanderbilt University Medical Center
- Study coordinator: Patrick, Anna Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.