Understanding lung disease in children with systemic juvenile idiopathic arthritis
Pathogenesis of Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease
This study is looking at how a serious lung problem in some kids with systemic juvenile idiopathic arthritis happens, and it aims to find new ways to help treat or prevent this issue by understanding how a certain part of their immune system works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11042812 on NIH RePORTER |
What this research studies
This research investigates the severe lung disease associated with systemic juvenile idiopathic arthritis (SJIA), which affects some children with this condition. The study aims to uncover the mechanisms behind lung inflammation driven by a specific immune response involving interferon gamma (IFNγ). By examining how this immune pathway affects lung macrophages, the research seeks to identify potential targeted treatments to prevent or manage this serious complication. The findings could lead to better therapeutic strategies for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with systemic juvenile idiopathic arthritis.
Not a fit: Patients who do not have systemic juvenile idiopathic arthritis or are over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce lung disease in children with systemic juvenile idiopathic arthritis.
How similar studies have performed: Other research has shown success in understanding immune responses in related conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Schulert, Grant Sanford — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Schulert, Grant Sanford
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.