Understanding lung disease in children with systemic juvenile idiopathic arthritis
Official title: Pathogenesis of Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11042812 · Data updated 2026-11-12
This study is looking at how a serious lung problem in some kids with systemic juvenile idiopathic arthritis happens, and it aims to find new ways to help treat or prevent this issue by understanding how a certain part of their immune system works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 6, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $525,487 |
| NIH project number | 5R01AR079524-04 |
| Project ID | NIH-11042812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have been diagnosed with systemic juvenile idiopathic arthritis.
✕Less likely to help
Patients who do not have systemic juvenile idiopathic arthritis or are over the age of 11 may not benefit from this research.
What this research studies
This research investigates the severe lung disease associated with systemic juvenile idiopathic arthritis (SJIA), which affects some children with this condition. The study aims to uncover the mechanisms behind lung inflammation driven by a specific immune response involving interferon gamma (IFNγ). By examining how this immune pathway affects lung macrophages, the research seeks to identify potential targeted treatments to prevent or manage this serious complication. The findings could lead to better therapeutic strategies for affected children.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce lung disease in children with systemic juvenile idiopathic arthritis.
How similar studies have gone: Other research has shown success in understanding immune responses in related conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Schulert, Grant Sanford — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Schulert, Grant Sanford
Related research
Other NIH-funded projects on the same topics.
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Deciphering What Drives Juvenile Idiopathic Arthritis in African American Children
This project looks at why African American children with juvenile idiopathic arthritis have more joint damage, using clinical data and genetic information to find factors that may explain the differences.
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Understanding how T cells make IFN-γ and IL-17 in kids with juvenile arthritis
A doctor-scientist at Vanderbilt is studying why certain immune cells in children with juvenile idiopathic arthritis produce inflammatory signals, with the goal of improving diagnosis and treatment.
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Lung disease linked to systemic juvenile idiopathic arthritis in children
This project looks at how ongoing immune activation and some arthritis medicines may cause lung inflammation and breathing problems in children with systemic juvenile idiopathic arthritis (SJIA).
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Linking JIA Registry with Claims Data to Improve Understanding of Juvenile Arthritis
A study will connect the CARRA JIA patient registry with a large national claims database to see how well registry data match real-world care and outcomes for children with juvenile idiopathic arthritis.
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Investigating the role of viruses and gut bacteria in arthritis flares in children
This study is looking at how certain viruses and bacteria in the gut might affect flare-ups of juvenile idiopathic arthritis in kids, hoping to find clues that could help manage these painful episodes better.
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Understanding how immune cells produce inflammatory signals in children with arthritis
This study is looking at how certain immune cells in children with juvenile idiopathic arthritis produce substances that cause inflammation, and it hopes to find genetic clues that could help improve how we diagnose and treat this condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.