Understanding how sepsis affects brain function in older adults
Neuroinflammatory mechanisms underlying sepsis-induced cognitive dysfunction
This study is looking at how sepsis affects thinking and memory in older adults, especially how inflammation in the brain might cause long-lasting issues, and it aims to understand the differences in brain responses between older and younger people to help find better ways to support those who have had sepsis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10525755 on NIH RePORTER |
What this research studies
This research investigates the effects of sepsis on cognitive function in older adults, particularly focusing on how inflammation in the brain may lead to long-term cognitive impairments. The study aims to identify the mechanisms behind these changes by examining the role of microglia, the brain's immune cells, and how their response differs in older individuals compared to younger ones. By using advanced animal models, the researchers will explore the relationship between age, Alzheimer's disease-related changes, and cognitive outcomes following sepsis. This comprehensive approach seeks to provide insights into the neurological impacts of sepsis and potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced sepsis or are at risk of developing cognitive impairments.
Not a fit: Patients who are younger or do not have a history of sepsis or cognitive dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive dysfunction in older adults following sepsis.
How similar studies have performed: Previous research has indicated that understanding the role of inflammation in cognitive decline has shown promise, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Harrison, Fiona Edith — Vanderbilt University Medical Center
- Study coordinator: Harrison, Fiona Edith
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.