Understanding how sepsis affects brain function in older adults
Neuroinflammatory mechanisms underlying sepsis-induced cognitive dysfunction
This study is looking at how sepsis affects thinking and memory in older adults, especially how inflammation in the brain might cause long-lasting problems, and it aims to find ways to help improve brain function for those who have had sepsis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10835675 on NIH RePORTER |
What this research studies
This research investigates the impact of sepsis on cognitive function in older adults, particularly focusing on how inflammation in the brain may lead to long-term cognitive impairments. The study aims to explore the role of microglia, the brain's immune cells, in causing memory and attention issues after sepsis. By using advanced animal models that better mimic the conditions of older adults, the researchers will assess how age and existing Alzheimer's-related changes in the brain influence recovery from sepsis. The findings could help identify new therapeutic targets to improve cognitive outcomes for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have suffered from sepsis and are experiencing cognitive difficulties.
Not a fit: Patients who are younger or have not experienced sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive dysfunction in older adults who have experienced sepsis.
How similar studies have performed: Previous research has shown that understanding neuroinflammatory responses can lead to significant advancements in treating cognitive dysfunction, suggesting this approach has potential for success.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Harrison, Fiona Edith — Vanderbilt University Medical Center
- Study coordinator: Harrison, Fiona Edith
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.