Understanding how oxidative stress affects heart failure
Novel Mechanisms of Oxidative Stress Response in Heart Failure
This study is looking at how oxidative stress affects heart failure and how a protein called Nrf2 helps the heart protect and heal itself, with the hope of finding new ways to improve treatments for people with heart issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10930191 on NIH RePORTER |
What this research studies
This research investigates the role of oxidative stress in heart failure, particularly how it impacts the heart's ability to manage damage and repair itself. The study focuses on the Nrf2 protein, which helps activate antioxidant and detoxification genes in response to oxidative stress. By examining the interactions of specific proteins and ribosomes during oxidative stress, researchers aim to uncover new mechanisms that could lead to better treatments for heart failure. Patients may benefit from insights gained about how to enhance the heart's protective responses against oxidative damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure, particularly those with a history of myocardial ischemia or infarction.
Not a fit: Patients with heart failure due to non-ischemic causes or those who are not experiencing oxidative stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Other research has shown promising results in understanding oxidative stress mechanisms in various conditions, suggesting that this approach could yield valuable insights for heart failure as well.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Chen, Qin M — University of Arizona
- Study coordinator: Chen, Qin M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.