Understanding how oxidative stress affects heart failure
Official title: Novel Mechanisms of Oxidative Stress Response in Heart Failure
Funded at University of Arizona · NIH-10930191 · Data updated 2026-11-12
This study is looking at how oxidative stress affects heart failure and how a protein called Nrf2 helps the heart protect and heal itself, with the hope of finding new ways to improve treatments for people with heart issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 23, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $625,316 |
| NIH project number | 1R56HL166330-01A1 |
| Project ID | NIH-10930191 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure, particularly those with a history of myocardial ischemia or infarction.
✕Less likely to help
Patients with heart failure due to non-ischemic causes or those who are not experiencing oxidative stress may not benefit from this research.
What this research studies
This research investigates the role of oxidative stress in heart failure, particularly how it impacts the heart's ability to manage damage and repair itself. The study focuses on the Nrf2 protein, which helps activate antioxidant and detoxification genes in response to oxidative stress. By examining the interactions of specific proteins and ribosomes during oxidative stress, researchers aim to uncover new mechanisms that could lead to better treatments for heart failure. Patients may benefit from insights gained about how to enhance the heart's protective responses against oxidative damage.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve heart function and outcomes for patients with heart failure.
How similar studies have gone: Other research has shown promising results in understanding oxidative stress mechanisms in various conditions, suggesting that this approach could yield valuable insights for heart failure as well.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Chen, Qin M — University of Arizona
- Study coordinator: Chen, Qin M
Related research
Other NIH-funded projects on the same topics.
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Protein translation control in heart failure under oxidative stress
This project looks at how heart cells manage oxidative stress and how a protein called Nrf2 is produced, which could reveal new ways to help people with heart failure.
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Oxidative stress, mitochondria, and heart failure in a mouse model and future neonatal heart failure studies
A mentored clinician–scientist program will study how oxidative stress affects heart cell powerplants and heart function, using a special mouse model, with plans to apply findings to neonatal heart disease in the future.
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Investigating how oxidative stress affects heart function in heart failure.
This study is looking at how oxidative stress affects heart health, especially in people with heart failure, and it aims to find new ways to help treat this condition, particularly for premature infants who are more vulnerable to heart issues.
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Investigating how oxidative stress affects heart function in heart failure.
This study is looking at how oxidative stress affects heart function, especially in people with heart failure, and aims to find new ways to help treat this condition, particularly for premature infants who are more vulnerable to heart issues.
-
Understanding how Nrf2 affects heart failure and communication between the heart and brain
This study is looking at how a specific protein called Nrf2 affects heart failure and the connection between the heart and brain, with the hope of finding new ways to help people manage their heart condition better.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.