Understanding how Nrf2 affects heart failure and communication between the heart and brain
Official title: Nrf2 regulation of oxidative stress in heart failure and extra vesicular communication
Funded at University of Nebraska Medical Center · NIH-10812217 · Data updated 2026-11-12
This study is looking at how a specific protein called Nrf2 affects heart failure and the connection between the heart and brain, with the hope of finding new ways to help people manage their heart condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $629,103 |
| NIH project number | 5R01HL153176-04 |
| Project ID | NIH-10812217 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic heart failure who may benefit from novel therapeutic strategies targeting oxidative stress.
✕Less likely to help
Patients with heart failure who do not have any underlying oxidative stress issues may not receive significant benefits from this research.
What this research studies
This research investigates the role of Nrf2 signaling in heart failure and how it relates to oxidative stress and communication between the heart and brain. The study aims to uncover the molecular mechanisms behind Nrf2 dysregulation and its impact on cardiac remodeling and sympathetic excitation. By examining the role of microRNAs and extracellular vesicles, the research seeks to understand how these factors contribute to heart failure and potentially influence treatment strategies. Patients may benefit from insights that could lead to new therapeutic approaches for managing heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce complications in patients with heart failure.
How similar studies have gone: Previous studies have shown promise in understanding the role of Nrf2 and microRNAs in cardiovascular health, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Zucker, Irving H — University of Nebraska Medical Center
- Study coordinator: Zucker, Irving H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.