Investigating how oxidative stress affects heart function in heart failure.
Official title: Oxidative Stress and Mitochondrial Dysfunction in Chemogenetic Heart Failure
Funded at Brigham and Women's Hospital · NIH-10897228 · Data updated 2026-11-12
This study is looking at how oxidative stress affects heart function, especially in people with heart failure, and aims to find new ways to help treat this condition, particularly for premature infants who are more vulnerable to heart issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $168,220 |
| NIH project number | 5K08HL168240-02 |
| Project ID | NIH-10897228 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of heart failure or those at risk due to conditions like premature birth.
✕Less likely to help
Patients with heart failure unrelated to oxidative stress or mitochondrial dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the impact of oxidative stress on heart function, particularly in the context of heart failure. The principal investigator, Dr. Fotios Spyropoulos, will use a specialized mouse model to generate oxidative stress in the heart and study its effects on mitochondrial function. The goal is to uncover the mechanisms linking oxidative stress to heart failure, which could lead to new treatment strategies. The findings may eventually be applied to better understand heart failure in premature infants, who are at high risk for such complications.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and outcomes for patients with heart failure.
How similar studies have gone: Previous research has shown promising results in understanding oxidative stress in heart conditions, indicating that this approach has potential for success.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Spyropoulos, Fotios — Brigham and Women's Hospital
- Study coordinator: Spyropoulos, Fotios
Related research
Other NIH-funded projects on the same topics.
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Protein translation control in heart failure under oxidative stress
This project looks at how heart cells manage oxidative stress and how a protein called Nrf2 is produced, which could reveal new ways to help people with heart failure.
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Oxidative stress, mitochondria, and heart failure in a mouse model and future neonatal heart failure studies
A mentored clinician–scientist program will study how oxidative stress affects heart cell powerplants and heart function, using a special mouse model, with plans to apply findings to neonatal heart disease in the future.
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Investigating how oxidative stress affects heart function in heart failure.
This study is looking at how oxidative stress affects heart health, especially in people with heart failure, and it aims to find new ways to help treat this condition, particularly for premature infants who are more vulnerable to heart issues.
-
Understanding how oxidative stress affects heart failure
This study is looking at how oxidative stress affects heart failure and how a protein called Nrf2 helps the heart protect and heal itself, with the hope of finding new ways to improve treatments for people with heart issues.
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This study is looking at how a specific protein called Nrf2 affects heart failure and the connection between the heart and brain, with the hope of finding new ways to help people manage their heart condition better.
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Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.