Understanding how mechanical stress affects bowel function after surgery
Enteric Glial Mechanotransduction and Mechanical Stress Induced Postoperative Ileus
This study is looking at how surgery can affect your bowel movements afterward, specifically how a special sensor in your body responds to pressure during the operation, with the goal of finding better ways to help you recover and feel better after gastrointestinal surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11029259 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind postoperative ileus (POI), a common complication after gastrointestinal surgeries. It focuses on how mechanical stress during surgery impacts bowel motility through a specific glial mechanosensor called Piezo-1. By using advanced models and techniques, including genetically modified mice and human tissue studies, the research aims to uncover new therapeutic strategies to improve recovery and reduce complications. Patients may benefit from insights that could lead to better management of bowel function post-surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing gastrointestinal surgeries who are at risk for postoperative ileus.
Not a fit: Patients who have not undergone gastrointestinal surgery or those with unrelated gastrointestinal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce the incidence of postoperative ileus and enhance recovery after gastrointestinal surgeries.
How similar studies have performed: Previous research has shown promising results in understanding mechanotransduction in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Christofi, Fedias Leontiou — Ohio State University
- Study coordinator: Christofi, Fedias Leontiou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.