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Clinical trial Recruiting at 1 site Interventional Ages 18 to 45 Women only

Restrictive versus liberal IV fluids during elective cesarean with spinal anesthesia

Official title: A Prospective Randomized Controlled Trial Comparing Restrictive and Liberal Intraoperative Fluid Strategies on Postoperative Nausea and Vomiting and Gastrointestinal Recovery After Elective Cesarean Section Under Spinal Anesthesia

Run by Nigde Omer Halisdemir University · NCT07440667 · Data updated 2026-11-12

This trial will test whether giving less versus more IV fluids during spinal anesthesia reduces nausea and speeds bowel recovery for women having an elective cesarean.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexWomen only
Enrollment160 (estimated)
SponsorNigde Omer Halisdemir University
Academic / other
Locations1 site (Niğde, Merkez)
StatusRecruiting
StartedMarch 4, 2026
Main results expectedJanuary 30, 2027
Study endsJanuary 30, 2027
Registry record updatedMarch 10, 2026
Trial IDNCT07440667 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women aged 18–45 with ASA physical status II scheduled for elective cesarean under spinal anesthesia who can give informed consent are the intended participants.

Probably not a fit

Patients with preeclampsia/eclampsia, significant cardiac, renal, or hepatic failure, coagulopathy, emergency cesarean, or those converted to general anesthesia are excluded and unlikely to benefit from the study interventions.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center, randomized, parallel-group trial comparing restrictive (≤3 mL/kg/h) and liberal (>3 mL/kg/h) intraoperative crystalloid strategies in women undergoing elective cesarean section under spinal anesthesia. Eligible patients aged 18–45 with ASA II will be randomized 1:1 at Niğde Ömer Halisdemir University Hospital. The primary outcome is the incidence of postoperative nausea and vomiting within 24 hours, and secondary outcomes include postdural puncture headache, time to first flatus, hypotension frequency, and vasopressor requirements. Intraoperative hemodynamics, fluid volumes, and postoperative recovery metrics will be recorded to compare maternal outcomes between the two fluid regimens.

Why it matters

Potential benefit: If successful, the selected fluid strategy could reduce nausea and speed gastrointestinal recovery after cesarean, improving comfort and informing optimal fluid management.

How similar studies have gone: Previous studies comparing restrictive and liberal intraoperative fluids in obstetric and non-obstetric surgery have shown mixed results, so the optimal approach remains unresolved.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Female patients aged 18-45 years
* ASA physical status II
* Scheduled for elective cesarean section under spinal anesthesia
* Provision of written informed consent

Exclusion Criteria:

* Emergency cesarean section
* Preeclampsia or eclampsia
* Known cardiac failure
* Known renal failure
* Known hepatic failure
* Coagulopathy
* Contraindication to spinal anesthesia
* Conversion to general anesthesia
* Major technical complications during spinal anesthesia
* Refusal to participate

Where it's running

  • Niğde Ömer Halisdemir University Hospital
    Niğde, Merkez, Turkey (Türkiye)     Recruiting

Study contacts

  • Principal investigator: Pınar Erdoğan, Assoc Prof — Niğde Ömer Halisdemir University Hospital
  • Study coordinator: Pınar Erdoğan, Assoc. Prof.
  • Email: pinar.erdogan@ohu.edu.tr
  • Phone: +905233646954

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
Cesarean Section 42Postoperative Nausea and Vomiting (PONV) 6Postdural Puncture Headache (PDPH) 2Postoperative Ileus 16Nigde Omer Halisdemir University 19
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.