Investigating how glial cells affect gut movement after surgery
Enteric glial ETBR signaling in postoperative ileus
This study is looking at how certain cells in the gut might affect digestion problems that can happen after surgery, and it aims to find ways to help patients recover better after gastrointestinal surgeries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10654809 on NIH RePORTER |
What this research studies
This research explores the role of enteric glial cells in postoperative ileus (POI) and gastrointestinal dysfunction following surgery. By examining the signaling pathways of endothelin (ET-1) in these glial cells, the study aims to uncover the mechanisms that disrupt gut motility after surgical procedures. The research involves both animal models and human subjects to validate findings and assess potential therapeutic strategies targeting these pathways. The ultimate goal is to improve recovery outcomes for patients undergoing gastrointestinal surgeries.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients scheduled for gastrointestinal surgeries who are at risk for postoperative ileus or gastrointestinal dysfunction.
Not a fit: Patients who have not undergone gastrointestinal surgery or those with unrelated digestive disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce postoperative complications and improve recovery times for patients after gastrointestinal surgery.
How similar studies have performed: Previous research has shown promising results in understanding the role of glial cells in gastrointestinal disorders, suggesting that this approach could yield significant insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Christofi, Fedias Leontiou — Ohio State University
- Study coordinator: Christofi, Fedias Leontiou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.