Understanding how lymphatic dysfunction leads to lung complications after transplant

Who could benefit from this research

What this research studies

This research investigates the role of lymphatic function in the development of bronchiolitis obliterans syndrome (BOS), a serious complication that can occur after lung transplantation. The study aims to understand how the loss of lymphatic function contributes to inflammation and lung injury, potentially leading to BOS. Researchers will use animal models to explore the interactions between lymphatic endothelial cells and immune cells, and how these interactions can be manipulated to protect against lung injury. By identifying the mechanisms involved, the research seeks to develop new strategies for preventing BOS in lung transplant patients.

Why it matters

Where this research is happening

• Children's Hosp of Philadelphia
  Philadelphia, United States Active

Researchers

• Principal investigator: Hancock, Wayne William — Children's Hosp of Philadelphia
• Study coordinator: Hancock, Wayne William

Related research

Other NIH-funded projects on the same topics.

• Lymphatic changes after lung transplant and risk of bronchiolitis obliterans

  Researchers are looking at how damage or repair of the lung's lymphatic vessels after transplant affects the chance of developing bronchiolitis obliterans in people who receive lung transplants.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11251739

• How respiratory viruses affect long-term lung damage after donor stem cell transplant

  Following people who had donor stem cell transplants to see how common respiratory viruses relate to long-term lung damage called bronchiolitis obliterans syndrome.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11237165

• Predicting early lung disease in children and young adults after stem cell transplant

  This work aims to find better ways to screen for and predict a serious lung condition called bronchiolitis obliterans syndrome (BOS) in children and young adults who have had a stem cell transplant.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11092102

• Investigating how respiratory viruses affect lung health in transplant patients

  This study is looking at how respiratory viruses affect lung health in people who have had a stem cell transplant and are dealing with bronchiolitis obliterans syndrome, and it will use home devices to keep track of their lung function over time to help catch any problems early.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-10995284

• Targeting early oral GVHD to improve mouth health after stem cell transplant

  A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11616478

• Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury

  A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11594128

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.