Understanding how lymphatic dysfunction leads to lung complications after transplant
Lymphatic Dysfunction and Development of Post-Transplant Obliterative Bronchiolitis
This study is looking at how problems with the lymphatic system might lead to a serious lung issue called bronchiolitis obliterans syndrome (BOS) after a lung transplant, and it aims to find ways to protect against this condition for patients who have had a transplant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11071175 on NIH RePORTER |
What this research studies
This research investigates the role of lymphatic function in the development of bronchiolitis obliterans syndrome (BOS), a serious complication that can occur after lung transplantation. The study aims to understand how the loss of lymphatic function contributes to inflammation and lung injury, potentially leading to BOS. Researchers will use animal models to explore the interactions between lymphatic endothelial cells and immune cells, and how these interactions can be manipulated to protect against lung injury. By identifying the mechanisms involved, the research seeks to develop new strategies for preventing BOS in lung transplant patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone lung transplantation and are at risk for developing bronchiolitis obliterans syndrome.
Not a fit: Patients who have not undergone lung transplantation or those with other unrelated lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent lung complications in transplant patients, enhancing their long-term health and graft survival.
How similar studies have performed: Previous research has shown promising results in understanding lymphatic function in other contexts, but this specific approach to BOS is novel and untested.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hancock, Wayne William — Children's Hosp of Philadelphia
- Study coordinator: Hancock, Wayne William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.