How respiratory viruses affect long-term lung damage after donor stem cell transplant
Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Cell Transplant Recipients
Following people who had donor stem cell transplants to see how common respiratory viruses relate to long-term lung damage called bronchiolitis obliterans syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11237165 on NIH RePORTER |
What this research studies
You would be followed over time after an allogeneic (donor) hematopoietic cell transplant to track respiratory infections and lung function. The team will collect samples to test for viruses like RSV, parainfluenza, metapneumovirus, and flu, including infections that cause no symptoms. You would use mobile home spirometry so lung function can be measured frequently and remotely, and those results will be compared with viral exposure over months to years. Multiple transplant centers will work together to map how repeated or asymptomatic viral infections line up with the start and progression of bronchiolitis obliterans syndrome.
Who could benefit from this research
Good fit: People who have received an allogeneic (donor) hematopoietic cell transplant, especially those with or at risk for chronic graft-versus-host disease affecting the lungs, are the main candidates.
Not a fit: People without a prior donor stem cell transplant or whose lung problems come from unrelated causes are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could identify virus-related triggers and timing that help prevent or slow lung damage in transplant survivors.
How similar studies have performed: Prior data indicate respiratory viruses can increase BOS risk and that home spirometry is feasible, but this long-term multicenter link between viral exposure and lung decline is relatively new.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Cheng, Guang-Shing — Fred Hutchinson Cancer Center
- Study coordinator: Cheng, Guang-Shing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.