Investigating how respiratory viruses affect lung health in transplant patients

Who could benefit from this research

What this research studies

This research focuses on understanding the impact of respiratory viruses on bronchiolitis obliterans syndrome (BOS) in patients who have undergone allogeneic hematopoietic cell transplantation. It aims to identify how these viruses contribute to lung dysfunction and poor health outcomes over time. By using mobile wireless home spirometry, the study will monitor lung function in patients, allowing for early diagnosis and better tracking of disease progression. The research will involve multiple centers and will follow patients longitudinally to gather comprehensive data on their respiratory health.

Why it matters

Where this research is happening

• Fred Hutchinson Cancer Center
  Seattle, United States Active

Researchers

• Principal investigator: Cheng, Guang-Shing — Fred Hutchinson Cancer Center
• Study coordinator: Cheng, Guang-Shing

Related research

Other NIH-funded projects on the same topics.

• Lymphatic changes after lung transplant and risk of bronchiolitis obliterans

  Researchers are looking at how damage or repair of the lung's lymphatic vessels after transplant affects the chance of developing bronchiolitis obliterans in people who receive lung transplants.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11251739

• How respiratory viruses affect long-term lung damage after donor stem cell transplant

  Following people who had donor stem cell transplants to see how common respiratory viruses relate to long-term lung damage called bronchiolitis obliterans syndrome.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11237165

• Predicting early lung disease in children and young adults after stem cell transplant

  This work aims to find better ways to screen for and predict a serious lung condition called bronchiolitis obliterans syndrome (BOS) in children and young adults who have had a stem cell transplant.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11092102

• Understanding how lymphatic dysfunction leads to lung complications after transplant

  This study is looking at how problems with the lymphatic system might lead to a serious lung issue called bronchiolitis obliterans syndrome (BOS) after a lung transplant, and it aims to find ways to protect against this condition for patients who have had a transplant.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11071175

• Targeting early oral GVHD to improve mouth health after stem cell transplant

  A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11616478

• Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury

  A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11594128

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.