Predicting early lung disease in children and young adults after stem cell transplant
Penetrating the “Black box”: Prediction of early Bronchiolitis obliterans in Pediatric Hematopoietic Stem Cell Transplant Recipients
This work aims to find better ways to screen for and predict a serious lung condition called bronchiolitis obliterans syndrome (BOS) in children and young adults who have had a stem cell transplant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11092102 on NIH RePORTER |
What this research studies
Bronchiolitis obliterans syndrome (BOS) is a severe lung disease that can happen after a stem cell transplant, and it's often caught too late in children. Our goal is to develop new tools, like blood tests and prediction models, to find BOS much earlier. We will look at specific proteins in blood samples from both children and adults to see if they can predict who is at risk. This will help doctors make better treatment decisions and potentially prevent the disease from getting worse.
Who could benefit from this research
Good fit: This research is relevant for children and young adults who have received a hematopoietic stem cell transplant and are at risk for or have developed bronchiolitis obliterans syndrome.
Not a fit: Patients who have not undergone a hematopoietic stem cell transplant or are not at risk for bronchiolitis obliterans syndrome would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier diagnosis and treatment for bronchiolitis obliterans syndrome, potentially improving survival and reducing long-term health problems for patients.
How similar studies have performed: This work is entirely novel, as there are currently no established biomarkers or predictive tools for bronchiolitis obliterans syndrome.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Myers, Kasiani — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Myers, Kasiani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.