Understanding how individual differences affect responses to acute respiratory distress syndrome
Investigating Individual Susceptibility and Host Response in Acute Respiratory Distress Syndrome
This study is looking at how our bodies' immune responses and genetic traits affect the risk of developing acute respiratory distress syndrome (ARDS) during serious illnesses like sepsis and COVID-19, with the hope of finding better treatments to help patients recover and survive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10894801 on NIH RePORTER |
What this research studies
This research investigates how individual susceptibility and immune responses contribute to acute respiratory distress syndrome (ARDS), particularly in the context of sepsis and COVID-19. By analyzing a large cohort of critically ill patients, the study aims to identify specific molecular traits that may influence treatment responses. Patients will be monitored over time, and their biosamples will be used to uncover genetic and molecular factors associated with ARDS risk and outcomes. The goal is to develop targeted therapies that can improve survival rates and recovery for those affected by ARDS.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been diagnosed with ARDS, particularly those with sepsis or COVID-19 related complications.
Not a fit: Patients who do not have ARDS or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments that significantly improve survival and recovery rates for patients with ARDS.
How similar studies have performed: Previous research has shown promise in understanding individual responses to ARDS, but this study aims to build on that knowledge with a novel and comprehensive approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Meyer, Nuala Jennings — University of Pennsylvania
- Study coordinator: Meyer, Nuala Jennings
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.