Understanding how individual differences affect responses to acute respiratory distress syndrome
Official title: Investigating Individual Susceptibility and Host Response in Acute Respiratory Distress Syndrome
Funded at University of Pennsylvania · NIH-10894801 · Data updated 2026-11-12
This study is looking at how our bodies' immune responses and genetic traits affect the risk of developing acute respiratory distress syndrome (ARDS) during serious illnesses like sepsis and COVID-19, with the hope of finding better treatments to help patients recover and survive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 19, 2022 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $955,499 |
| NIH project number | 5R35HL161196-03 |
| Project ID | NIH-10894801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been diagnosed with ARDS, particularly those with sepsis or COVID-19 related complications.
✕Less likely to help
Patients who do not have ARDS or related conditions may not benefit from this research.
What this research studies
This research investigates how individual susceptibility and immune responses contribute to acute respiratory distress syndrome (ARDS), particularly in the context of sepsis and COVID-19. By analyzing a large cohort of critically ill patients, the study aims to identify specific molecular traits that may influence treatment responses. Patients will be monitored over time, and their biosamples will be used to uncover genetic and molecular factors associated with ARDS risk and outcomes. The goal is to develop targeted therapies that can improve survival rates and recovery for those affected by ARDS.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments that significantly improve survival and recovery rates for patients with ARDS.
How similar studies have gone: Previous research has shown promise in understanding individual responses to ARDS, but this study aims to build on that knowledge with a novel and comprehensive approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Meyer, Nuala Jennings — University of Pennsylvania
- Study coordinator: Meyer, Nuala Jennings
Related research
Other NIH-funded projects on the same topics.
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Identifying ARDS patients who may benefit from paralytics guided by high-frequency clinical data
This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
-
Resilience endotypes and early ARDS detection using biomarkers and AI
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
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PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
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Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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Immune, hormone, and muscle energy links to recovery after ARDS
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.