Understanding how HIV replicates in different animal hosts
Official title: Determinants of retroviral replication in non-native hosts for modeling HIV infection
Funded at North Carolina State University Raleigh · NIH-11088644 · Data updated 2026-11-12
This study is looking at how a virus that causes AIDS interacts with macaques to create better models for understanding HIV, which could help improve treatments and vaccines for people living with the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $746,254 |
| NIH project number | 7R01AI172615-02 |
| Project ID | NIH-11088644 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of HIV infection or those living with HIV who may benefit from improved treatment options.
✕Less likely to help
Patients who are not at risk for HIV or those who have already achieved viral suppression may not receive direct benefits from this research.
What this research studies
This research investigates how HIV-1, a virus that causes AIDS, interacts with different species, particularly macaques, to improve models for studying the virus. By using chimeric viruses that combine elements of HIV and simian immunodeficiency virus (SIV), researchers aim to create better models that mimic human infection. The study focuses on enhancing the replication of these chimeric viruses in macaques, which is crucial for developing effective vaccines and treatments. Patients may benefit from advancements in HIV prevention and treatment strategies derived from these improved models.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and treatments for HIV infection in humans.
How similar studies have gone: Previous research using similar chimeric virus models has shown promise in understanding HIV infection and developing vaccines, indicating a potential for success in this approach.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Sharma, Amit — North Carolina State University Raleigh
- Study coordinator: Sharma, Amit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.