Blood cell mutations, chromosome changes, and heart disease in people living with HIV
Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)
This project looks at whether age-related blood cell mutations and large chromosome changes help explain why people living with HIV have a higher risk of heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11373117 on NIH RePORTER |
What this research studies
People living with HIV will give blood samples so researchers can look for clonal hematopoiesis (age-related mutations in blood cells) and mosaic chromosomal alterations. Scientists will also measure inflammation markers tied to the NLRP3/IL-1β/IL-6 pathways and collect information about heart disease history and outcomes. Genetic, biomarker, and clinical record data will be combined to see whether these blood changes are linked to higher cardiovascular risk in people with HIV. The work uses samples and clinical data from cohorts at UCLA and follows health records over time to connect molecular findings with heart events.
Who could benefit from this research
Good fit: Adults living with HIV, particularly older adults or those on antiretroviral therapy, who can provide blood samples and allow access to their health records are ideal candidates.
Not a fit: People without HIV or those whose cardiovascular disease is driven by causes unrelated to inflammation are unlikely to directly benefit from this research.
Why it matters
Potential benefit: If successful, this could point to immune-related targets and new therapies to reduce heart attack and stroke risk in people with HIV.
How similar studies have performed: Previous studies in the general population have linked clonal hematopoiesis and inflammatory pathways to higher heart disease risk, but applying these findings specifically to people with HIV is a more recent effort.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Hsue, Priscilla Y. — University of California Los Angeles
- Study coordinator: Hsue, Priscilla Y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.