Clonal blood mutations and chromosome changes linked to heart disease in people with HIV
Official title: Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)
Funded at University of California Los Angeles · NIH-11181024 · Data updated 2026-11-12
Researchers will look for whether age-related blood mutations and large chromosome changes raise heart disease risk in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $732,435 |
| NIH project number | 5R01HL170600-03 |
| Project ID | NIH-11181024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults living with HIV, particularly older adults or those with cardiovascular risk factors, who can provide blood samples and medical history.
✕Less likely to help
People without HIV or those unable or unwilling to give blood samples or attend clinic visits are unlikely to receive direct benefit from this project.
What this research studies
If you live with HIV, this project would collect blood samples and health information to look for specific age-related mutations in blood cells (CHIP) and large mosaic chromosomal changes (mCAs). The team will compare these findings with measures of inflammation and cardiovascular health to see how they relate to heart disease risk. They will also study immune signaling pathways like NLRP3/IL-1β/IL-6 that might link these blood changes to heart problems. Results come from lab sequencing of blood cells and analysis of clinical records and biomarkers.
Why it matters
Potential benefit: If successful, the work could point to blood-based markers and immune pathways that help predict or reduce heart disease risk in people living with HIV.
How similar studies have gone: Prior studies in the general population have linked clonal hematopoiesis and mosaic chromosomal alterations to higher heart disease risk and preliminary work shows increased CHIP and mCAs in people with HIV, but the direct link to CVD in HIV has not yet been proven.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Hsue, Priscilla Y. — University of California Los Angeles
- Study coordinator: Hsue, Priscilla Y.
Related research
Other NIH-funded projects on the same topics.
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Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
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Lp(a) and HIV: Understanding Heart Disease Risk in HIV Patients
This program looks at how Lipoprotein(a) contributes to higher heart disease risk in people with HIV and what Lp(a) levels mean for future treatments.
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Understanding how age-related blood changes affect heart disease risk in people with HIV
This study looks at whether certain blood-level genetic changes and chromosome alterations in people living with HIV relate to higher risk of heart disease.
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Blood cell mutations, chromosome changes, and heart disease in people living with HIV
This project looks at whether age-related blood cell mutations and large chromosome changes help explain why people living with HIV have a higher risk of heart disease.
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How Lp(a) levels affect heart and artery disease risk in people with HIV
This project looks at whether higher levels of a blood lipid called Lp(a) raise the chance of heart and artery disease for people living with HIV.
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Investigating the link between aging, HIV, and heart disease
This study is looking at how getting older and living with HIV can raise the chances of heart problems in older adults, and it aims to find ways to help reduce that risk by understanding the biological changes involved.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.