Clonal blood mutations and chromosome changes linked to heart disease in people with HIV
Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11181024
Researchers will look for whether age-related blood mutations and large chromosome changes raise heart disease risk in people living with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11181024 on ClinicalTrials.gov |
What this research studies
If you live with HIV, this project would collect blood samples and health information to look for specific age-related mutations in blood cells (CHIP) and large mosaic chromosomal changes (mCAs). The team will compare these findings with measures of inflammation and cardiovascular health to see how they relate to heart disease risk. They will also study immune signaling pathways like NLRP3/IL-1β/IL-6 that might link these blood changes to heart problems. Results come from lab sequencing of blood cells and analysis of clinical records and biomarkers.
Who could benefit from this research
Good fit: Ideal candidates are adults living with HIV, particularly older adults or those with cardiovascular risk factors, who can provide blood samples and medical history.
Not a fit: People without HIV or those unable or unwilling to give blood samples or attend clinic visits are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, the work could point to blood-based markers and immune pathways that help predict or reduce heart disease risk in people living with HIV.
How similar studies have performed: Prior studies in the general population have linked clonal hematopoiesis and mosaic chromosomal alterations to higher heart disease risk and preliminary work shows increased CHIP and mCAs in people with HIV, but the direct link to CVD in HIV has not yet been proven.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HSUE, PRISCILLA Y. — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: HSUE, PRISCILLA Y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus, Atherosclerotic Cardiovascular Disease