Investigating the link between aging, HIV, and heart disease
Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11145531
This study is looking at how getting older and living with HIV can raise the chances of heart problems in older adults, and it aims to find ways to help reduce that risk by understanding the biological changes involved.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11145531 on ClinicalTrials.gov |
What this research studies
This research explores how aging and HIV infection contribute to an increased risk of cardiovascular disease (CVD) in older adults. It focuses on understanding the role of clonal hematopoiesis and chromosomal alterations in this population. By examining the biological mechanisms involved, the study aims to identify potential therapeutic targets that could help reduce CVD risk among people living with HIV. Participants may undergo assessments to evaluate their cardiovascular health and genetic factors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are living with HIV.
Not a fit: Patients who are not living with HIV or are under the age of 65 may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular disease in older adults living with HIV.
How similar studies have performed: Previous research has shown that understanding the genetic factors associated with cardiovascular disease can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HSUE, PRISCILLA Y. — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: HSUE, PRISCILLA Y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus