Understanding how abdominal aortic aneurysms progress
Official title: Novel Mechanisms underlying abdominal aortic aneurysm progression
Funded at University of Missouri-Columbia · NIH-11046660 · Data updated 2026-11-12
This study is looking into how inflammation and cell death in the aorta can make abdominal aortic aneurysms worse, with the goal of finding new ways to help manage or treat this serious condition for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $586,009 |
| NIH project number | 5R01HL173025-02 |
| Project ID | NIH-11046660 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with abdominal aortic aneurysms or those at high risk for developing this condition.
✕Less likely to help
Patients without abdominal aortic aneurysms or those with other unrelated vascular conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms that lead to the progression of abdominal aortic aneurysms (AAA), a serious condition that can result in life-threatening ruptures. The study focuses on the role of inflammation and cell death in the aorta, particularly how these processes weaken the artery wall. By examining the responses of specific cells in the aorta, the research aims to identify potential targets for new treatments that could prevent AAA from worsening. Patients may benefit from insights gained into how to better manage or treat this condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent the progression of abdominal aortic aneurysms and reduce the risk of rupture.
How similar studies have gone: Other research has shown promise in understanding the biological mechanisms of aortic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Chen, Shiyou — University of Missouri-Columbia
- Study coordinator: Chen, Shiyou
Related research
Other NIH-funded projects on the same topics.
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How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
MOF’s role in weakening the aorta and stopping aneurysm growth
Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
-
Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm
A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.
-
Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
-
Using genetics to uncover how abdominal aortic aneurysms develop
A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.