Understanding how abdominal aortic aneurysms progress
Novel Mechanisms underlying abdominal aortic aneurysm progression
This study is looking into how inflammation and cell death in the aorta can make abdominal aortic aneurysms worse, with the goal of finding new ways to help manage or treat this serious condition for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11046660 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that lead to the progression of abdominal aortic aneurysms (AAA), a serious condition that can result in life-threatening ruptures. The study focuses on the role of inflammation and cell death in the aorta, particularly how these processes weaken the artery wall. By examining the responses of specific cells in the aorta, the research aims to identify potential targets for new treatments that could prevent AAA from worsening. Patients may benefit from insights gained into how to better manage or treat this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with abdominal aortic aneurysms or those at high risk for developing this condition.
Not a fit: Patients without abdominal aortic aneurysms or those with other unrelated vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent the progression of abdominal aortic aneurysms and reduce the risk of rupture.
How similar studies have performed: Other research has shown promise in understanding the biological mechanisms of aortic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Chen, Shiyou — University of Missouri-Columbia
- Study coordinator: Chen, Shiyou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.