Type 1 Diabetes after Acute Pancreatitis: Immune Clues from the Pacific Northwest
Official title: Type 1 Diabetes in Acute Pancreatitis Consortium – Pacific Northwest Clinical Center: Immune Pathogenesis of Post-Pancreatitis T1D
Funded at Benaroya Research Inst at Virginia Mason · NIH-11413767 · Data updated 2026-11-12
A multi-center study follows adults after an acute pancreatitis episode to understand how some develop Type 1 diabetes and what immune factors are involved.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 16, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $517,100 |
| NIH project number | 5U01DK127404-07 |
| Project ID | NIH-11413767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a history of acute pancreatitis who are at risk for or concerned about developing Type 1 diabetes.
✕Less likely to help
People without a history of pancreatitis or diabetes are unlikely to benefit from this study.
What this research studies
This project tracks adults who have had acute pancreatitis over time to see how many develop diabetes and which type they get. It uses modern immune profiling to identify immune system patterns that may signal progression to Type 1 diabetes after pancreatitis. Researchers will collect clinical data, blood samples, and endocrine measurements to map risks and immune changes. The goal is to better predict who is at risk and to reveal potential targets for prevention or treatment.
Why it matters
Potential benefit: If successful, patients who have had pancreatitis could receive earlier risk assessment and new approaches to prevent or manage Type 1 diabetes after an pancreatitis episode.
How similar studies have gone: Previous work has suggested immune factors influence diabetes after pancreatitis, but this study aims for prospective, detailed immune profiling in a large cohort.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Speake, Cate — Benaroya Research Inst at Virginia Mason
- Study coordinator: Speake, Cate
Related research
Other NIH-funded projects on the same topics.
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Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
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Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
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Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
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Diabetes After Acute Pancreatitis: Understanding Progression and Genetics at Cedars-Sinai
This grant supports Cedars-Sinai’s clinical center as part of a national effort to study why some adults develop brittle type 1 diabetes after an acute pancreatitis episode and how genes influence this risk.
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Understanding how acute pancreatitis may lead to type 1 diabetes
This study is looking at how having acute pancreatitis might lead to type 1 diabetes, and it aims to find early warning signs and risk factors to help identify people who could be at risk for developing diabetes after pancreatitis.
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Cedars‑Sinai program on diabetes that follows acute pancreatitis
This program follows people who had acute pancreatitis to find biological and genetic signs that predict who will develop diabetes afterward.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.