Sponsor or institution
Clinical trials and research at Benaroya Research Inst at Virginia Mason
As of November 12, 2026, Find a Trial lists 80 NIH-funded research projects at this institution, with $80.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 80NIH research projects
NIH-funded research (newest 40 of 80)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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T cells and the switch from pre-autoimmunity to autoimmune disease
A study following people at risk for type 1 diabetes and people with Down syndrome to understand how certain T cells may shift toward causing autoimmune disease.
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Genetic and epigenetic control of T cell function in autoimmune disease
This grant aims to understand how genetic and epigenetic changes affect how T cells behave in autoimmune diseases to find ways to reduce harmful immune responses.
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Immune Tolerance Network (ITN) for immune tolerance therapies across autoimmune and allergic diseases
A national network runs clinical trials to test new immune-tolerance therapies that could help people with autoimmune and allergic diseases.
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Immune Tolerance Network for safer, more effective immune therapies
A nationwide network tests new immune therapies to help people with autoimmune diseases, allergies, and transplant patients reach better control of their immune system.
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Immune tolerance research network for safer transplant and autoimmune therapies
A national effort tests new treatments that make the immune system tolerate transplanted organs and fight autoimmune and allergic diseases more safely.
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Immune Tolerance Network for allergy, autoimmunity, and transplantation
A large NIH program tests new immune-tolerance therapies to help people with autoimmune diseases, allergies, and transplant patients.
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Immune tolerance therapy for immune-driven diseases
A national collaborative effort tests new immune-tolerance treatments to help people with autoimmune and allergic diseases.
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Understanding how non-coding genetic variants influence autoimmune diseases in immune cells
A researcher is studying how non-coding genetic differences affect immune cell behavior to help better prevent and treat autoimmune diseases.
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Isogenic 3D beta cell and immune cell model for type 1 diabetes
Researchers are building a patient-friendly 3D system using stem-cell–derived beta cells and immune cells to study how type 1 diabetes develops and why beta cells are damaged.
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Reprogramming skin cells by skin-homing CD4+ T cells
A study to understand how specific immune cells in the skin change nearby skin cells and how this affects skin inflammation and healing.
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Alpha-chain TCR metaclones in Type 1 Diabetes
Researchers are studying specific immune cells in people with Type 1 diabetes to understand how they target insulin-producing cells and whether these signals seen in blood reflect what happens in the pancreas.
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Type 1 Diabetes after Acute Pancreatitis: Immune Clues from the Pacific Northwest
A multi-center study follows adults after an acute pancreatitis episode to understand how some develop Type 1 diabetes and what immune factors are involved.
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Autoantibodies and ulcerative colitis: how avb6 antibodies may drive disease
This NIH grant aims to understand how antibodies against a gut cell protein (αvβ6) may actively contribute to ulcerative colitis and what that means for future treatments.
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Type 1 Diabetes TrialNet Clinical Network Hub
A national network hub is funded to speed up screening, recruitment, and sharing results for trials aimed at preserving beta cell function in people with type 1 diabetes or at risk for it.
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Understanding inflammaging in Down syndrome to improve immune health
This grant studies why people with Down syndrome age their immune system faster and how this affects infections, vaccines, and autoimmune problems, with the goal of new therapies.
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Understanding how regulatory T cells work in type 1 diabetes by studying expanded Tregs in teens
This grant studies how a patient’s own regulatory T cells behave in type 1 diabetes to find ways that could help protect insulin-producing cells.
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How IL-23 Blockade in Crohn's Disease Changes Immune Cells
This study looks at how the IL-23 blocking therapy risankizumab affects immune cells in people with Crohn’s disease.
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Genetic clues about dangerous colitis-causing T cells
This grant looks at how genetic differences in people with inflammatory bowel disease influence the behavior of disease-causing T cells called Th17 cells.
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Commensal-specific CD8+ T cells and gut immunity in health and disease
This grant explores how gut bacteria shape CD8+ T cells to maintain intestinal health and what goes wrong in autoimmune gut disease.
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Clonal expansion as a marker of disease activity in early type 1 diabetes
This grant looks at whether expanding islet antigen–specific T and B cells can signal disease activity in early type 1 diabetes and help predict progression.
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LITAF and membrane repair in infection and inflammation
A patient-friendly description of how LITAF may help cells repair damaged membranes during infections and inflammatory conditions, potentially reducing harmful inflammation.
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How immune systems in adults with rheumatoid arthritis react to common respiratory viruses
This project looks at immune responses to everyday respiratory viruses in adults with rheumatoid arthritis compared with healthy adults.
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How children's immune systems fight respiratory viruses when they have asthma, allergies, or obesity
This project is looking at how the immune systems of children with asthma, allergies, or obesity respond over time to respiratory viral infections compared with children without those conditions.
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Advanced immune testing of blood and nasal samples for viral, allergen, and autoimmune responses
This project uses advanced lab tests to look at how immune cells in blood and nasal samples respond to respiratory viruses, allergens, and autoimmune triggers in people at higher risk.
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Immune profiling of respiratory viruses in vulnerable people
This project maps how the immune system responds to respiratory viruses in people who are especially at risk, using samples like nasal swabs and blood.
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Patient recruitment and sample collection for asthma and rheumatoid arthritis
This project enrolls children with asthma and adults with rheumatoid arthritis to collect blood, nasal swabs, and sputum before and after respiratory viral infections.
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Understanding immune responses to respiratory viruses in people at higher risk
This project looks at how the immune system reacts to common respiratory viruses in children with asthma, allergies, or obesity and in adults with rheumatoid arthritis.
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Regulation of Intestinal Immunity and Repair by Integrins (UC context)
A study exploring how specific gut cell proteins called integrins may control inflammation and healing in ulcerative colitis, with the goal of uncovering mechanisms that could prevent or lessen disease symptoms.
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Plasmacytoid dendritic cells and IgA antibodies in lupus
This research looks at how a type of immune cell (plasmacytoid dendritic cells) and IgA autoantibodies interact in people with lupus to better understand disease activity.
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How skin helper T cells reshape skin cells
This project looks at how immune cells in the skin change skin cells and may help people with inflammatory skin conditions like eczema.
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Understanding gut CD8+ T cells that respond to friendly bacteria
This project will create new lab tools to better understand how certain immune cells in the small intestine respond to harmless gut bacteria, aiming to inform future treatments for gut inflammation.
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Characterizing non-coding genetic variants that affect immune cells
Researchers are studying how common DNA differences outside genes influence immune diseases by testing their effects in immune cells to better understand risk and guide new therapies.
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Understanding how respiratory viruses affect vulnerable populations
This study is looking at how the immune system reacts to respiratory viruses in older adults and people with health issues, so we can find better ways to treat them, and patients may help by sharing samples or information about their health.
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Understanding how respiratory viruses affect vulnerable populations
This study is looking at how the immune system responds to respiratory viruses in older adults and people with health issues, to find ways to improve prevention and treatment, and it may involve patients sharing samples or information to help with this research.
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Investigating innovative approaches to health improvement.
This study is all about finding better ways to help patients improve their health by trying out different treatments and getting feedback from both patients and doctors to make sure the results really matter to everyone involved.
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A core facility for advanced immune profiling techniques.
This study is all about using new techniques to take a closer look at your immune system, helping doctors understand how it works in different health conditions, so they can create better tests and personalized treatments just for you.
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Understanding how respiratory viruses affect vulnerable populations
This study is looking at how the immune system responds to respiratory viruses in older adults and people with health issues, and it hopes to find clues that could lead to better treatments, so your participation by sharing samples or information could really help!
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Core administrative support for research activities
This study is all about making it easier for researchers at the Benaroya Research Institute to work together and share resources, so they can discover new ways to help patients like you.
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A clinical core facility for advancing medical research.
This study is all about creating a helpful team that makes it easier for patients to join exciting new treatments and clinical trials, so they can get better care and access to the latest medical advancements.
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Helping the immune system learn tolerance for transplants, autoimmune disease, and allergies
This program develops and tests treatments that teach the immune system to accept transplants and reduce autoimmune attacks and allergic reactions for people with those conditions.
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