Sponsor or institution
Clinical trials and research at Columbia University Health Sciences
As of November 12, 2026, Find a Trial lists 1,900 NIH-funded research projects at this institution, with $1.3 billion in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 1900NIH research projects
NIH-funded research (newest 40 of 1900)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Precision phenotyping of emphysema in the elderly: a study in diverse adults
Researchers will look at CT scans and lung tests in older adults to understand different forms of emphysema and how they relate to health outcomes.
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HPV-based cervical cancer screening and treatment implementation in resource-limited settings
A collaborative project to help doctors in South Africa put HPV-based screening and same-day treatment for cervical cancer into routine care, so more people get fast, effective care.
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Cervical cancer screening and treatment rollout in resource-poor settings
A team from Columbia and the University of Cape Town is testing how to best implement affordable, same-day HPV-based screen-and-treat for cervical cancer in public health settings.
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Understanding SCN3A-related Developmental Epileptic Encephalopathy and Finding Better Treatments
This NIH grant focuses on how SCN3A gene variants cause developmental epileptic encephalopathy and aims to develop more effective therapies for affected patients.
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mChoice: Boosting PrEP Use and Adherence for Black and Latino MSM with Tailored Training and Support
A national study to help Black and Latino men who have sex with men start and stick with PrEP through culturally matched provider training and patient support.
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M-CaRE: Mobile clinics and a smart heart-lung care tool for multimorbidity
A mobile, multilingual tool plus community health workers will help screen and manage high blood pressure and COPD in diverse adult patients, especially in underserved areas.
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Small molecules to block Slit2/ROBO in glioblastoma
A study to test small molecule drugs that block Slit2/ROBO signals to help treat glioblastoma in patients.
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Gut-brain clues in Parkinson’s disease: supplement to a large registry
A plant-wide supplement to an NIH program will enroll people with Parkinson’s, with and without GI symptoms, plus healthy controls, to study how gut function, brain signals, and sleep rhythms relate to Parkinson’s symptoms.
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Exploring how oxidative stress and ferroptosis affect frontotemporal dementia
A study using human iPSC-derived neurons from people with frontotemporal dementia to see how reactive oxygen species and a cell death process called ferroptosis relate to disease features.
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Social media support for Alzheimer's caregivers powered by AI chat help
A caregiver-focused program for families of people with Alzheimer's and related dementias uses an AI-enhanced social media approach to provide daily supportive messages and online discussions.
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Cerebellar Deep Brain Stimulation for Spinocerebellar Ataxias
A preliminary clinical trial will test delivering electrical stimulation to the cerebellum in people with spinocerebellar ataxia to see if it improves balance and coordination.
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ROMA:Cog trial compares single vs multiple arterial grafts for brain health after CABG
A study in adults undergoing heart bypass surgery will test whether one arterial graft or multiple arterial grafts affect brain function and brain injury markers.
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Uncovering genetic causes of congenital hearing loss in diverse populations
A fast, family-based genetic study aims to find new genes linked to congenital hearing loss in children from Africa, Europe, and Asia to improve early diagnosis.
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Genes linked to inherited deafness in children
A research project at Columbia is looking for the hidden genes that cause congenital nonsyndromic hearing loss in young children so families can get earlier diagnosis and better care.
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Predictors of Keeping Off Weight After Losing It in Adults with Obesity
Researchers will study why some people who lose about 10% of their body weight after lifestyle changes regain weight, by looking at behavior and body signals in adults with overweight or obesity.
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Gut-brain communication in Parkinson’s disease for better symptoms and daily life
This project enrolls people with Parkinson’s disease and healthy controls to build a big registry and study how gut function, brain signals, sleep, and circadian rhythms relate to PD symptoms.
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Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
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Glucocorticoids and critical illness outcomes in ICU patients
A researcher team at Columbia University will study how glucocorticoids affect short- and long-term outcomes for people who survive critical illness, including mental health and recovery aspects.
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Understanding urinary infections: how bacteria hijack iron at the bladder
A study explored how bladder bacteria use iron and heme to cause infections, aiming to uncover new ways to prevent and treat urinary tract infections.
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Urothelial Health: Understanding How Skin-Like Bladder Cells Regenerate
A study at Columbia University Health Sciences will look at how bladder lining cells repair themselves after injury to find ways to keep the bladder barrier strong.
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Genetic testing to improve diagnosis and care for children with urinary tract birth defects
A study in kids with congenital kidney and urinary tract problems will see how exome sequencing can improve diagnosis and guide clinical care.
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Administrative Core for Urology Research Center (O’Brien Center)
A central Core that supports a collaborative Urology research center to understand UTIs and urinary tract problems by coordinating leadership, data sharing, and administrative activities.
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ICAP Clinical Trials Unit for HIV Prevention at Columbia University
A program supporting HIV prevention research across multiple sites to help people at risk access better prevention options and care.
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Distal Airway Dysfunction in Young Adults after Childhood 9/11 Exposure
Kids exposed to the World Trade Center disaster may have hidden breathing problems later, and this study looks to see if those early exposures relate to ongoing airway issues in young adulthood.
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CureGN: Understanding and Improving Care for Glomerular Diseases
A large, ongoing study follows adults and children with glomerular diseases to learn how these conditions progress and respond to treatment, with the goal of informing better care.
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Cure Glomerulonephropathy Network for Glomerular Disease Patients
A national network studies kids and adults with common kidney diseases to understand how they progress and how treatments work.
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Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
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Novel therapeutic to protect the gut after radiation
A new GI-directed treatment given after radiation exposure may reduce gut damage and improve survival in people exposed to high-dose radiation.
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A new GI-focused treatment to reduce radiation damage after exposure
A potential GI-targeted therapy given after radiation exposure may help protect the gut and improve survival in people affected by radiation injuries.
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Making HIV testing in hospital dental clinics easier and more used
A hospital-based dental program in NYC tests and screens patients for HIV and explores adding at-home self-testing to boost reach and lighten clinician workload.
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Single-session intervention and interpersonal therapy for teen depression in Mozambican clinics
A pilot, real-world trial tests if a one-visit program plus coaching helps depressed teens in Mozambique access care and feel better.
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Understanding how genes and aging affect female ovarian health
A funded project at Columbia University aims to uncover how aging changes the ovaries at the gene level and to identify genetic factors linked to when women reach menopause.
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Control of Type I Interferon Production in Response to Candida
A study at Columbia University focuses on how the body’s type I interferon system responds to Candida infections and what this means for treatment of dangerous bloodstream infections.
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Fungal Melanin and Calcium Signals in Lung Cells
Scientists are studying how a fungus called Aspergillus fumigatus uses its pigment melanin to change calcium signaling in lung cells, which could weaken the body’s initial defenses.
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Bruton’s Tyrosine Kinase and defense against Aspergillus fumigatus
This project explores how blocking BTK affects the body’s ability to fight a serious fungal infection in people who may be treated for autoimmune diseases or B cell cancers.
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Public Health Data Science Training in Eastern Africa (APHREA-DST)
A training program to build public health data science skills in Eastern Africa and connect them with U.S. and African partners to improve health insights.
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How diet affects white blood cells and sickle cell disease
A study looks at how nutrition, from early life to adulthood, influences sickle cell disease by examining neutrophils and disease severity in people with SCD and in a mouse model.
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Columbia UC NCORP: Expanding Cancer Clinical trials for communities
A program that helps people with cancer access a wide range of cancer trials and high-quality care in their local community.
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Targeting the tumor-immune interface to beat Richter’s transformation in CLL
A NIH-funded project at Columbia University aims to understand and block how chronic lymphocytic leukemia progresses to a more deadly form, with the goal of guiding better treatments for patients.
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Columbia HIV/AIDS Clinical Trials Unit focuses on advancing prevention and treatment in NYC
A patient-facing CTU in NYC coordinates clinical trials to improve HIV prevention and care for people living with HIV and those at risk.
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