Exploring how oxidative stress affects leukemia using advanced imaging techniques
Official title: Interrogation of the oxidative-stress-induced leukemia program in vivo using metabolic imaging
Funded at Sloan-Kettering Inst Can Research · NIH-11043492 · Data updated 2026-11-12
This study is looking at how stress affects the metabolism of acute myeloid leukemia (AML) cells, hoping to find weaknesses that could lead to new treatments, so patients can learn more about their specific type of leukemia and possible new options for care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $87,947 |
| NIH project number | 3R01CA283578-02S1 |
| Project ID | NIH-11043492 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia, particularly those who have experienced treatment resistance.
✕Less likely to help
Patients with other types of leukemia or those who do not have acute myeloid leukemia may not benefit from this research.
What this research studies
This research investigates the metabolic changes in acute myeloid leukemia (AML) caused by oxidative stress. By utilizing innovative imaging methods, the study aims to identify specific metabolic vulnerabilities in leukemia cells that could be targeted for treatment. The approach focuses on understanding how certain genetic mutations influence the metabolism of these cancer cells, which may lead to new therapeutic strategies. Patients may benefit from insights gained into their specific leukemia subtype and potential new treatment options.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with acute myeloid leukemia by targeting specific metabolic pathways.
How similar studies have gone: Previous research has shown promise in targeting metabolic vulnerabilities in leukemia, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Keshari, Kayvan R — Sloan-Kettering Inst Can Research
- Study coordinator: Keshari, Kayvan R
Related research
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Targeting leukemia metabolism with metabolic imaging in AML
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Investigating how oxidative stress affects leukemia using advanced imaging techniques
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.