Exploring how oxidative stress affects leukemia using advanced imaging techniques
Interrogation of the oxidative-stress-induced leukemia program in vivo using metabolic imaging
This study is looking at how stress affects the metabolism of acute myeloid leukemia (AML) cells, hoping to find weaknesses that could lead to new treatments, so patients can learn more about their specific type of leukemia and possible new options for care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11043492 on NIH RePORTER |
What this research studies
This research investigates the metabolic changes in acute myeloid leukemia (AML) caused by oxidative stress. By utilizing innovative imaging methods, the study aims to identify specific metabolic vulnerabilities in leukemia cells that could be targeted for treatment. The approach focuses on understanding how certain genetic mutations influence the metabolism of these cancer cells, which may lead to new therapeutic strategies. Patients may benefit from insights gained into their specific leukemia subtype and potential new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia, particularly those who have experienced treatment resistance.
Not a fit: Patients with other types of leukemia or those who do not have acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with acute myeloid leukemia by targeting specific metabolic pathways.
How similar studies have performed: Previous research has shown promise in targeting metabolic vulnerabilities in leukemia, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Keshari, Kayvan R — Sloan-Kettering Inst Can Research
- Study coordinator: Keshari, Kayvan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.