Investigating how oxidative stress affects leukemia using advanced imaging techniques
Interrogation of the oxidative-stress-induced leukemia program in vivo using metabolic imaging
This study is looking at how stress in the body affects the way leukemia cells use sugar to grow, with the goal of finding new ways to treat acute myeloid leukemia (AML) and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10876462 on NIH RePORTER |
What this research studies
This research focuses on acute myeloid leukemia (AML), a complex cancer with various genetic mutations. It aims to understand how oxidative stress influences the metabolism of leukemia cells, particularly through a specific enzyme involved in glucose metabolism. By using innovative imaging methods, the study seeks to identify new therapeutic targets that could improve treatment outcomes for patients with AML. The approach includes both genetic and pharmacological strategies to disrupt the metabolic pathways that leukemia cells rely on for growth.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia who may have not responded well to existing treatments.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with any form of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the metabolic vulnerabilities of leukemia cells, potentially improving survival rates for patients with AML.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in leukemia, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Keshari, Kayvan R — Sloan-Kettering Inst Can Research
- Study coordinator: Keshari, Kayvan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.