Investigating how oxidative stress affects leukemia using advanced imaging techniques
Official title: Interrogation of the oxidative-stress-induced leukemia program in vivo using metabolic imaging
Funded at Sloan-Kettering Inst Can Research · NIH-10876462 · Data updated 2026-11-12
This study is looking at how stress in the body affects the way leukemia cells use sugar to grow, with the goal of finding new ways to treat acute myeloid leukemia (AML) and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $679,961 |
| NIH project number | 5R01CA283578-02 |
| Project ID | NIH-10876462 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia who may have not responded well to existing treatments.
✕Less likely to help
Patients with other types of leukemia or those who are not diagnosed with any form of cancer may not benefit from this research.
What this research studies
This research focuses on acute myeloid leukemia (AML), a complex cancer with various genetic mutations. It aims to understand how oxidative stress influences the metabolism of leukemia cells, particularly through a specific enzyme involved in glucose metabolism. By using innovative imaging methods, the study seeks to identify new therapeutic targets that could improve treatment outcomes for patients with AML. The approach includes both genetic and pharmacological strategies to disrupt the metabolic pathways that leukemia cells rely on for growth.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the metabolic vulnerabilities of leukemia cells, potentially improving survival rates for patients with AML.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in leukemia, indicating that this approach has potential for success.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Keshari, Kayvan R — Sloan-Kettering Inst Can Research
- Study coordinator: Keshari, Kayvan R
Related research
Other NIH-funded projects on the same topics.
-
Targeting leukemia metabolism with metabolic imaging in AML
Researchers are testing a new way to image and target the energy metabolism of acute myeloid leukemia to find vulnerabilities that could lead to better treatments.
-
Understanding how metabolism drives acute myeloid leukemia
This research explores how specific metabolic changes in leukemia cells could lead to new ways to treat acute myeloid leukemia (AML), especially for patients whose disease returns or resists current treatments.
-
Exploring how oxidative stress affects leukemia using advanced imaging techniques
This study is looking at how stress affects the metabolism of acute myeloid leukemia (AML) cells, hoping to find weaknesses that could lead to new treatments, so patients can learn more about their specific type of leukemia and possible new options for care.
-
Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
-
Caregiver-led mobile tool to support healthy habits for kids treated for ALL
A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.
-
Targeting the SCP4 pathway in acute myeloid leukemia (AML)
Aims to uncover how the SCP4 signaling pathway drives AML and how it could be blocked to help patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.