Targeting Factor XII to Slow Ovarian Cancer Spread and Blood Clots

Who could benefit from this research

What this research studies

This project looks at how Factor XII contributes to both cancer progression and clotting in high-grade ovarian cancer. Researchers will use human tumor samples and mouse models to test what happens when FXII functions are blocked, aiming to slow tumor spread and lower the risk of clots. The work will translate findings from cells and animals toward potential therapies that could benefit patients with ovarian cancer who are at risk for VTE. The study involves understanding how cancer cells and immune cells interact in a prothrombotic environment and whether FXII-targeted approaches can disrupt those interactions.

Why it matters

Where this research is happening

• Louis Stokes Cleveland VA Medical Center
  Cleveland, United States Active

Researchers

• Principal investigator: Stavrou, Evi X. — Louis Stokes Cleveland VA Medical Center
• Study coordinator: Stavrou, Evi X.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.