START Network for Promising Novel Drug Testing in Subarachnoid Hemorrhage
Official title: START (Subarachnoid hemorrhage Translational Advanced Research pre-Trial) Network for Promising Novel Drug Testing
Funded at University of Florida · NIH-11367161 · Data updated 2026-11-12
A network of three sites will test two potential treatments in a late-stage, animal model study of subarachnoid hemorrhage to help improve outcomes for patients who suffer this brain injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $611,097 |
| NIH project number | 1R01NS144324-01A1 |
| Project ID | NIH-11367161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient recruitment in this phase; results will inform future trials in individuals with subarachnoid hemorrhage.
✕Less likely to help
This grant does not enroll patients now; it is a preclinical study.
What this research studies
This project aims to make preclinical testing more like human trials by using a blinded, multi-site design that mirrors phase 3 studies. It will explore tocilizumab, an IL-6 blocker, and resveratrol, a SIRT1 agonist, in mouse models of SAH to see if they reduce brain injury and improve recovery. The team will focus on rigorous timing, generalizability, and blinding to better translate findings to patients in the future.
Why it matters
Potential benefit: If successful, the findings could guide future human trials and bring safer, more effective therapies for SAH patients closer to clinical use.
How similar studies have gone: Past preclinical failures highlight the need for rigorous, translatable designs; this approach builds on lessons from previous SAH research to improve predictability.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Hoh, Brian Lim — University of Florida
- Study coordinator: Hoh, Brian Lim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.