Manganese-based compound as a potential therapy for subarachnoid hemorrhage
Official title: Initial Safety and Target-Site Evaluation of a Manganese-Porphyrin-Based Compound for Subarachnoid Hemorrhage Treatment
Funded at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center · NIH-11373497 · Data updated 2026-11-12
A new manganese porphyrin-based drug is being explored as a possible treatment to reduce brain injury after a subarachnoid hemorrhage.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Barrow Neurological Institute at St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $464,514 |
| NIH project number | 1R21NS145098-01A1 |
| Project ID | NIH-11373497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with or at risk of subarachnoid hemorrhage who could participate in translational studies or future trials of neuroprotective agents.
✕Less likely to help
Patients without SAH or related brain vascular injuries are unlikely to benefit from this specific research.
What this research studies
This project tests MnP-05, a small molecule designed to mimic the brain’s natural antioxidant defenses, in models of subarachnoid hemorrhage. Researchers will evaluate whether the drug reaches the brain at the target site and produces the desired biological effects, following guidelines to ensure relevance to human disease. The study emphasizes translating preclinical findings into information that could support future human trials, with attention to safety and pharmacology. The work is conducted by a multi-investigator team at Barrow Neurological Institute to advance potential therapies for SAH-related brain injury.
Why it matters
Potential benefit: If successful, this approach could lead to a new treatment that protects the brain after SAH and improves recovery.
How similar studies have gone: Previous studies in similar antioxidant strategies have shown mixed results; this project aims to strengthen translational evidence for brain-penetrant agents.
Where this research is happening
-
Barrow Neurological Institute at St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Hashimoto, Tomoki — Barrow Neurological Institute at St. Joseph's Hospital and Medical Center
- Study coordinator: Hashimoto, Tomoki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.