Adropin as a shield for the brain after a brain hemorrhage
Official title: Neurovascular protection by adropin in acute neural injury from subarachnoid hemorrhage
Funded at University of Florida · NIH-11380727 · Data updated 2026-11-12
A potential treatment with adropin is being studied to protect brain cells after a subarachnoid hemorrhage and reduce stroke-like damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $374,407 |
| NIH project number | 5R01NS124620-05 |
| Project ID | NIH-11380727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have suffered a subarachnoid hemorrhage and are at risk for cerebral infarction could benefit from treatments developed from this research.
✕Less likely to help
This research is focused on acute brain injury mechanisms and may not benefit individuals without a brain hemorrhage.
What this research studies
This project looks at how adropin might help preserve brain function after a bleed in the brain by supporting blood flow and reducing oxidative stress. Researchers will explore how adropin affects the brain’s nitric oxide system and endothelial cells under injury conditions. The work combines basic science with experiments that model acute brain injury to see if adropin can lessen damage and improve outcomes for patients.
Why it matters
Potential benefit: If successful, adropin could become a therapy to reduce brain injury and improve recovery after a subarachnoid hemorrhage.
How similar studies have gone: Previous work suggests adropin interacts with the brain’s nitric oxide system and may protect the blood-brain barrier, but direct evidence in SAH is ongoing.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Hoh, Brian Lim — University of Florida
- Study coordinator: Hoh, Brian Lim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.