Cognitive screening after an aneurysmal brain bleed
Official title: Promoting cognitive screening and assessment post-aneurysmal subarachnoid hemorrhage
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11468520 · Data updated 2026-11-12
Using patient questionnaires to find thinking and memory problems in people recovering from aneurysmal subarachnoid hemorrhage.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 11, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $251,676 |
| NIH project number | 7R21NR021052-02 |
| Project ID | NIH-11468520 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have survived an aneurysmal subarachnoid hemorrhage (typically middle-aged adults) and are in outpatient follow-up would be the ideal candidates.
✕Less likely to help
People without a history of aneurysmal subarachnoid hemorrhage or those whose cognitive problems are already diagnosed and treated are unlikely to benefit from participation.
What this research studies
If you survived an aneurysmal subarachnoid hemorrhage, this project would use a set of patient-reported questionnaires (Neuro-QoL) to look for cognitive symptoms that often go undiagnosed. The team plans to compare questionnaire results with standard care and neuropsychological testing to figure out when patients should be referred for in-depth evaluation. The goal is to create a clearer pathway so people with hidden thinking or memory problems get timely referrals to cognitive rehabilitation. The work builds on preliminary data showing many survivors have undetected cognitive issues and that targeted interventions can help.
Why it matters
Potential benefit: If successful, more survivors could be identified early and connected to cognitive rehabilitation that improves daily function and quality of life.
How similar studies have gone: Preliminary data and previous work show many cognitive problems after aSAH are undetected and that cognitive rehabilitation can improve outcomes, so this approach is promising rather than entirely untested.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Stanfill, Ansley Grimes — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Stanfill, Ansley Grimes
Related research
Other NIH-funded projects on the same topics.
-
Molecularly mapping early brain injury after brain bleed using human brain organoids and patient CSF
Scientists are studying how early brain injury after aneurysmal subarachnoid hemorrhage happens in people, by using patient CSF and human brain organoids to find what signals cause damage and why women may have worse outcomes.
-
Understanding metabolic changes after brain hemorrhage
This study is looking at how a serious brain condition called aneurysmal subarachnoid hemorrhage affects the body's metabolism and inflammation, with the goal of finding ways to predict how well patients will recover by analyzing blood samples.
-
Using Satralizumab to treat complications from brain aneurysms.
This study is looking at how well the drug Satralizumab can help people recover after a brain aneurysm by reducing complications like vasospasm, and it’s designed for patients who have had this type of hemorrhage.
-
Identifying brain injury risks in patients with aneurysmal subarachnoid hemorrhage using brain activity monitoring.
This study is looking at how to better manage blood pressure for people who have had a brain bleed from an aneurysm, by closely monitoring their brain activity to find the best targets for blood flow, which could help prevent further complications and improve recovery.
-
Improving cognitive assessment after brain hemorrhages for better patient outcomes
This study is looking to improve how we spot and understand thinking problems in people who have had a brain bleed, especially focusing on African American and rural patients who might not get the help they need, so we can help them live better lives.
-
Blood test to predict delayed brain injury after an aneurysm bleed
This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.