Silent brain injuries after brain bleed may predict dementia risk

Who could benefit from this research

What this research studies

This study will follow people who survived spontaneous intracerebral hemorrhage to see if tiny, undetected brain injuries seen on MRI are tied to worse thinking and memory in the future. Researchers will track MRI changes, such as white matter hyperintensities, and measure inflammation markers over time while also testing cognitive functions. The goal is to identify biomarkers that could signal higher risk for vascular cognitive impairment and dementia so clinicians can tailor follow-up care. Participation would involve periodic imaging, blood tests, and cognitive assessments during the study window.

Why it matters

Where this research is happening

• Rush University Medical Center
  Chicago, United States Active

Researchers

• Principal investigator: Garg, Rajeev Kumar — Rush University Medical Center
• Study coordinator: Garg, Rajeev Kumar

Related research

Other NIH-funded projects on the same topics.

• Hidden small strokes after a brain bleed and risk of thinking and memory problems

  This project looks at whether hidden small strokes seen on MRI after a spontaneous brain bleed predict thinking and memory problems in survivors.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11194507

• Investigating silent brain infarcts in patients with spontaneous brain hemorrhage and their link to cognitive decline.

  This study is looking at people who have survived a brain bleed to see if hidden brain damage might be affecting their thinking skills, with the hope of finding clues that could help doctors better support their brain health in the future.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11052110

• Global picture of dementia risk and memory loss across the world

  A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.

  NIH research University of New South Wales · Sydney, Australia · NIH-11603263

• Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease

  This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.

  NIH research Yale University · New Haven, United States · NIH-11533213

• Statin use after lobar intracerebral hemorrhage

  This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11518526

• Statin use after lobar brain hemorrhage

  This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11518525

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.