Hidden small strokes after a brain bleed and risk of thinking and memory problems
Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular contributions to Cognitive Impairment and Dementia (VCID)
['FUNDING_R01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-11194507
This project looks at whether hidden small strokes seen on MRI after a spontaneous brain bleed predict thinking and memory problems in survivors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11194507 on ClinicalTrials.gov |
What this research studies
If I join, doctors will get MRI scans soon after my brain bleed to look for small, silent strokes that I wouldn't notice. They will give regular memory and thinking tests over time and repeat MRI scans to watch for white matter changes. Blood tests will be done to measure signs of chronic inflammation that might link the silent strokes to cognitive decline. The research will combine these imaging, cognitive, and blood measures to see who is most likely to develop vascular-related memory and thinking problems.
Who could benefit from this research
Good fit: Ideal candidates are adults who survived a spontaneous intracerebral hemorrhage and can undergo MRI scans and follow-up cognitive testing.
Not a fit: People without a prior spontaneous brain bleed or those unable to have MRI scans would not be eligible and would not directly benefit from this research.
Why it matters
Potential benefit: If successful, this could help identify people at higher risk of dementia after a brain bleed so they can get closer monitoring and earlier interventions.
How similar studies have performed: Similar work has linked silent brain infarcts to cognitive decline in other groups and early data hint at the same pattern after brain bleeds, but it has not been definitively confirmed in this population.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARG, RAJEEV KUMAR — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: GARG, RAJEEV KUMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.