Investigating silent brain infarcts in patients with spontaneous brain hemorrhage and their link to cognitive decline.
Official title: Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular contributions to Cognitive Impairment and Dementia (VCID)
Funded at Rush University Medical Center · NIH-11052110 · Data updated 2026-11-12
This study is looking at people who have survived a brain bleed to see if hidden brain damage might be affecting their thinking skills, with the hope of finding clues that could help doctors better support their brain health in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $471,246 |
| NIH project number | 1R01NS135614-01A1 |
| Project ID | NIH-11052110 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have survived spontaneous intracerebral hemorrhage and are experiencing or at risk for cognitive impairment.
✕Less likely to help
Patients who have not experienced spontaneous intracerebral hemorrhage or those without cognitive impairment may not benefit from this research.
What this research studies
This research focuses on patients who have survived spontaneous intracerebral hemorrhage (sICH) and are at risk for developing cognitive impairment and dementia. The study aims to identify silent brain infarcts (SBIs) using MRI scans, which are often undetectable but may contribute to cognitive decline. By examining the relationship between SBIs, cognitive outcomes, and other factors like white matter hyperintensities and systemic inflammation, the research seeks to uncover important biomarkers that could predict cognitive impairment in these patients. This could lead to better understanding and management of cognitive health in sICH survivors.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and management of cognitive decline in patients who have experienced spontaneous intracerebral hemorrhage.
How similar studies have gone: Previous studies have shown that silent brain infarcts are linked to cognitive decline in the general population, suggesting that this approach may yield valuable insights in sICH patients as well.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Garg, Rajeev Kumar — Rush University Medical Center
- Study coordinator: Garg, Rajeev Kumar
Related research
Other NIH-funded projects on the same topics.
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Silent brain injuries after brain bleed may predict dementia risk
A study using MRI and cognitive tests to see if hidden brain injuries after spontaneous intracerebral hemorrhage help forecast later cognitive decline.
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Hidden small strokes after a brain bleed and risk of thinking and memory problems
This project looks at whether hidden small strokes seen on MRI after a spontaneous brain bleed predict thinking and memory problems in survivors.
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Global picture of dementia risk and memory loss across the world
A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
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Statin use after lobar intracerebral hemorrhage
This trial compares continuing versus stopping statins in people who had a lobar intracerebral hemorrhage to see how that affects repeat brain bleeds, strokes, heart attacks, and recovery over two years.
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Statin use after lobar brain hemorrhage
This trial compares stopping versus continuing statin medicine in people who had a lobar brain bleed to learn effects on repeat bleeding and future heart or stroke events.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.