Investigating silent brain infarcts in patients with spontaneous brain hemorrhage and their link to cognitive decline.
Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular contributions to Cognitive Impairment and Dementia (VCID)
This study is looking at people who have survived a brain bleed to see if hidden brain damage might be affecting their thinking skills, with the hope of finding clues that could help doctors better support their brain health in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11052110 on NIH RePORTER |
What this research studies
This research focuses on patients who have survived spontaneous intracerebral hemorrhage (sICH) and are at risk for developing cognitive impairment and dementia. The study aims to identify silent brain infarcts (SBIs) using MRI scans, which are often undetectable but may contribute to cognitive decline. By examining the relationship between SBIs, cognitive outcomes, and other factors like white matter hyperintensities and systemic inflammation, the research seeks to uncover important biomarkers that could predict cognitive impairment in these patients. This could lead to better understanding and management of cognitive health in sICH survivors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have survived spontaneous intracerebral hemorrhage and are experiencing or at risk for cognitive impairment.
Not a fit: Patients who have not experienced spontaneous intracerebral hemorrhage or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and management of cognitive decline in patients who have experienced spontaneous intracerebral hemorrhage.
How similar studies have performed: Previous studies have shown that silent brain infarcts are linked to cognitive decline in the general population, suggesting that this approach may yield valuable insights in sICH patients as well.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Garg, Rajeev Kumar — Rush University Medical Center
- Study coordinator: Garg, Rajeev Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.